ArticleCommunications biology2018
Pinopsin evolved as the ancestral dim-light visual opsin in vertebrates.
Article in Communications biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Comparative phenotypic analysis of rhodopsin supports stepwise evolution of dim-light vision in early vertebrates.Molecular biology and evolution · 2026Article
- Pinopsin Regulates Melatonin Production and Daily Locomotor Activity: Functional Insights From Gene-Edited Xenopus Tadpoles.Journal of pineal research · 2026Article
- Monochromatic Photophase Light Alters Diurnal Profiles of Melatonin Pathway Indoles in the Rat Pineal Gland.International journal of molecular sciences · 2025Article
- Evolution of the Nonvisual and Visual Opsin Gene Repertoire in Ray-Finned Fishes.Genome biology and evolution · 2025Article
- Evolution of Pineal Nonvisual Opsins in Lizards and the Tuatara and Identification of Lepidopsin: A New Opsin Gene.Genome biology and evolution · 2025Article
- An Extensive Survey of Vertebrate-specific, Nonvisual Opsins Identifies a Novel Subfamily, Q113-Bistable Opsin.Genome biology and evolution · 2025Article
- Functional diversification process of opsin genes for teleost visual and pineal photoreceptions.Cellular and molecular life sciences : CMLS · 2024Article
- Diversity and Molecular Evolution of Nonvisual Opsin Genes across Environmental, Developmental, and Morphological Adaptations in Frogs.Molecular biology and evolution · 2024Article
- Deep Diversity: Extensive Variation in the Components of Complex Visual Systems across Animals.Cells · 2022Review
- Photoreceptor physiology and evolution: cellular and molecular basis of rod and cone phototransduction.The Journal of physiology · 2022Review
- Light-induced shifts in opsin gene expression in the four-eyed fishFrontiers in neuroscience · 2022Article
- Rhodopsins: An Excitingly Versatile Protein Species for Research, Development and Creative Engineering.Frontiers in chemistry · 2022Review
- Evolutionary adaptation of visual pigments in geckos for their photic environment.Science advances · 2021Article
- Insights into the evolutionary origin of the pineal color discrimination mechanism from the river lamprey.BMC biology · 2021Article
- Type II Opsins in the Eye, the Pineal Complex and the Skin ofFrontiers in neuroanatomy · 2021Review
- Metabolism of Melatonin Synthesis-Related Indoles in the Turkey Pineal Organ and Its Modification by Monochromatic Light.International journal of molecular sciences · 2020Article
- Zebrafish Circadian Clock Entrainment and the Importance of Broad Spectral Light Sensitivity.Frontiers in physiology · 2020Article
- Evolutionary history of teleost intron-containing and intron-less rhodopsin genes.Scientific reports · 2019Article
- Evolution of the calcium feedback steps of vertebrate phototransduction.Open biology · 2018Article
- Pinopsin evolved as the ancestral dim-light visual opsin in vertebrates.Communications biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pinopsin is the opsin most closely related to vertebrate visual pigments on the phylogenetic tree. This opsin has been discovered among many vertebrates, except mammals and teleosts, and was thought to exclusively function in their brain for extraocular photoreception. Here, we show the possibility that pinopsin also contributes to scotopic vision in some vertebrate species. Pinopsin is distributed in the retina of non-teleost fishes and frogs, especially in their rod photoreceptor cells, in addition to their brain. Moreover, the retinal chromophore of pinopsin exhibits a thermal isomerization rate considerably lower than those of cone visual pigments, but comparable to that of rhodopsin. Therefore, pinopsin can function as a rhodopsin-like visual pigment in the retinas of these lower vertebrates. Since pinopsin diversified before the branching of rhodopsin on the phylogenetic tree, two-step adaptation to scotopic vision would have occurred through the independent acquisition of pinopsin and rhodopsin by the vertebrate lineage.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.