Evidence map›Paper›PMID 30302399›Full record

ArticleCommunications biology2018

Doxorubicin induces caspase-mediated proteolysis of KV7.1.

Anne Strigli, Christian Raab, Sabine Hessler, Tobias Huth, Adam J T Schuldt, Christian Alzheimer, Thomas Friedrich, Paul W Burridge, Mark Luedde, Michael Schwake

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Integrative analysis of KCNQ1 variants reveals molecular mechanisms of type 1 long QT syndrome pathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Anne StrigliInstitute of Biochemistry, Christian Albrechts University of Kiel, Otto-Hahn-Platz 9, 24118, Kiel, Germany.
Christian RaabInstitute of Biochemistry, Christian Albrechts University of Kiel, Otto-Hahn-Platz 9, 24118, Kiel, Germany.
Sabine HesslerInstitute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 17, 91054, Erlangen, Germany.
Tobias HuthInstitute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 17, 91054, Erlangen, Germany.
Adam J T SchuldtDepartment of Pharmacology and Center for Pharmacogenomics, Feinberg School of Medicine, Northwestern University, 320 East Superior Street, Searle Building 8-450, Chicago, IL, 60611, USA.
Christian AlzheimerInstitute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 17, 91054, Erlangen, Germany.
Thomas FriedrichInstitut für Chemie PC 14, Technische Universität Berlin, Straße des 17. Juni 135, 10623, Berlin, Germany.ORCID http://orcid.org/0000-0003-2835-2895
Paul W BurridgeDepartment of Pharmacology and Center for Pharmacogenomics, Feinberg School of Medicine, Northwestern University, 320 East Superior Street, Searle Building 8-450, Chicago, IL, 60611, USA.
Mark LueddeDepartment of Internal Medicine III, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany.
Michael SchwakeInstitute of Biochemistry, Christian Albrechts University of Kiel, Otto-Hahn-Platz 9, 24118, Kiel, Germany. schwake@northwestern.edu.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DENorthwestern University · USChristian-Albrechts-Universität zu Kiel · DETechnische Universität Berlin · DEUniversity Hospital Schleswig-Holstein · DE

Funding

Genomic Prediction of Doxorubicin-Induced CardiotoxicityR01CA220002 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BURRIDGE, PAUL W., STRANGER, BARBARA E · 2018 to 2022
$1.8M
6 · The paper itself

Abstract

K

Identifiers

PMID30302399
PMCPMC6162258
OpenAlexW2951891682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.