ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2018
Early affective changes and increased connectivity in preclinical Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Amygdalar Pattern Similarity to Negative and Neutral Images, Ratings of the Images, and PET-Measured Amyloid and Tau Levels in Older Adults Without Dementia.Affective science · 2026Article
- Network-level functional connectivity is associated with longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer's disease.Research square · 2026Article
- Distinct patterns of spontaneous brain activity in mild cognitive impairment patients stratified by cerebrospinal fluid biomarkers.Frontiers in aging neuroscience · 2026Article
- Protocol for an intergenerational randomized controlled trial to enhance physical activity in older adults at risk for Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2025Article
- Gait impairment associated with neuroimaging biomarkers in Alzheimer's disease.Scientific reports · 2025Article
- Reward system atrophy relates to heightened feelings of physical closeness in Alzheimer's disease.Social cognitive and affective neuroscience · 2025Article
- Medial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer's Disease.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Reductions in the white-gray functional connectome in preclinical Alzheimer's disease and their associations with amyloid and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Salience network segregation mediates the effect of tau pathology on mild behavioral impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Change in Depressive Symptoms and Longitudinal Regional Amyloid Accumulation in Unimpaired Older Adults.JAMA network open · 2024Article
- Medial amygdalar tau is associated with anxiety symptoms in preclinical Alzheimer's disease.bioRxiv : the preprint server for biology · 2024Article
- Salience Network Segregation Mediates the Effect of Tau Pathology on Mild Behavioral Impairment.medRxiv : the preprint server for health sciences · 2024Article
- Increased Cortical Thickness in Alzheimer's Disease.Annals of neurology · 2024Article
- A novel spatiotemporal graph convolutional network framework for functional connectivity biomarkers identification of Alzheimer's disease.Alzheimer's research & therapy · 2024Article
- Lost in space(s): Multimodal neuroimaging of disorientation along the Alzheimer's disease continuum.Human brain mapping · 2024Article
- Predicting Brain Amyloid Status Using the National Institute of Health Toolbox (NIHTB) for Assessment of Neurological and Behavioral Function.The journal of prevention of Alzheimer's disease · 2024Article
- The subcortical default mode network and Alzheimer's disease: a systematic review and meta-analysis.Brain communications · 2024Article
- Resting-state functional connectivity changes in older adults with sleep disturbance and the role of amyloid burden.Molecular psychiatry · 2023Article
- The Impact of Dance Movement Interventions on Psychological Health in Older Adults without Dementia: A Systematic Review and Meta-Analysis.Brain sciences · 2023Review
- Sex differences in default mode network connectivity in healthy aging adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
introductionAffective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity in a "salience network" attuned to emotionally significant stimuli. The trajectory of affective changes in preclinical Alzheimer's disease, and its relationship to this network, is unknown.
methodsOne hundred one cognitively normal older adults received longitudinal assessments of affective symptoms, then amyloid-PET. We hypothesized amyloid-positive individuals would show enhanced emotional reactivity associated with salience network connectivity. We tested whether increased global connectivity in key regions significantly related to affective changes.
resultsIn participants later found to be amyloid positive, emotional reactivity increased with age, and interpersonal warmth declined in women. These individuals showed higher global connectivity within the right insula and superior temporal sulcus; higher superior temporal sulcus connectivity predicted increasing emotional reactivity and decreasing interpersonal warmth.
conclusionsAffective changes should be considered an early preclinical feature of Alzheimer's disease. These changes may relate to higher functional connectivity in regions critical for social-emotional processing.
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