ArticleInternational journal of hematologic oncology2017
Untreated chronic lymphocytic leukemia in Lebanese patients: an observational study using standard karyotyping and FISH.
Article in International journal of hematologic oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Prognostic impact of chronic lymphocytic leukemia comorbidity index in a young population: a real-world evidence study of a national gulf region cohort.BMC cancer · 2024Article
- Evaluation of the CLL-IPI and IPS-E Prognostic Indices in a Young Middle Eastern Population with Chronic Lymphocytic Leukemia: A Retrospective Analysis at the Kuwait Cancer Control Center.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2023Article
- Application of an Artificial Neural Network in the Diagnosis of Chronic Lymphocytic Leukemia.Cureus · 2019Article
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10 authors.
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Abstract
aimWe aimed to understand the biology of chronic lymphocytic leukemia (CLL) patients in Lebanon. MATERIALS &
methodsWe applied conventional cytogenetic and FISH studies on Lebanese patients diagnosed with CLL and undergoing a watch and wait approach.
resultsOur study disclosed 53.6% of patients with aberrant karyotypes among which 26.7% were complex karyotypes. Genetic aberrations included del(13q14) 46.4%, 14q32 translocation in 25%, trisomy 12 in 14.3%, del(17p13) and del(11q22) in 7.1% each. The deletion of 6q21/6q23 was not found in any of our patients.
conclusionThe higher prevalence of del(13q14) as a sole abnormality could be the primary event in inducing CLL. The del(17p13) and del(11q22) followed as potential drivers for progression in CLL patients with a watch and wait approach.
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