ArticleGastroenterology & hepatology2018
Perianal Fistulas in Patients With Crohn's Disease, Part 1: Current Medical Management.
Article in Gastroenterology & hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Early diagnosis of Crohn's disease in patients presenting with a perianal fistula: systematic review and development of a perianal red flags index.Techniques in coloproctology · 2025Pooled it
- Non-mucinous adenocarcinomas and squamous cell carcinomas of the anal region masquerading as abscess or fistula: a retrospective analysis and systematic review of literature.Journal of cancer research and clinical oncology · 2022Pooled it
- Prediction tool for early identification of patients at risk of Crohn's disease in perianal fistulas and abscesses (PREFAB): Analysis of a prospective pilot study at a non-academic, teaching centre in the Netherlands.Techniques in coloproctology · 2025Article
- Epidemiology, treatment patterns, and associated risk factors in perianal fistulizing Crohn's disease: A systematic literature review.World journal of gastrointestinal surgery · 2025Article
- Diagnosing Crohn's disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn's disease in perianal fistulas (PREFAB).Journal of Crohn's & colitis · 2025Article
- Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn's perianal fistulas.World journal of gastrointestinal surgery · 2023Article
- Exploring Health-Related Quality of Life in Patients with Anal Fistulas: A Comprehensive Study.Life (Basel, Switzerland) · 2023Article
- Vedolizumab more likely to be discontinued than ustekinumab in anti-TNF-experienced patients with fistulizing Crohn's disease.Therapeutic advances in gastroenterology · 2023Article
- Disease- and Medication-Specific Differences of the Microbial Spectrum in Perianal Fistulizing Crohn's Disease-Relevant Aspects for Antibiotic Therapy.Biomedicines · 2022Article
- Management of Enterocutaneous Fistula: A Review.JNMA; journal of the Nepal Medical Association · 2022Review
- The Essential Role of a Multidisciplinary Approach in Inflammatory Bowel Diseases: Combined Medical-Surgical Treatment in Complex Perianal Fistulas in CD.Clinics in colon and rectal surgery · 2022Review
- Diagnostic Features of Perianal Fistula in Patients With Crohn's Disease: Analysis of a Japanese Claims Database.Crohn's & colitis 360 · 2021Article
- Dysbiosis in a canine model of human fistulizing Crohn's disease.Gut microbes · 2020Article
- A Failure to Communicate: Disentangling the Causes of Perianal Fistulæ in Crohn's Disease and Anal Squamous Cell Cancer.Digestive diseases and sciences · 2020Article
- Maneuvering Clinical Pathways for Crohn's Disease.Current gastroenterology reports · 2019Review
- Perianal Fistulas in Patients With Crohn's Disease, Part 2: Surgical, Endoscopic, and Future Therapies.Gastroenterology & hepatology · 2018Article
- Ambulatory Surgery for Perianal Crohn's Disease: Study of Feasibility.Gastroenterology research and practice · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite significant advances in the treatment of luminal inflammatory bowel disease, the treatment of perianal fistulas remains a clinical challenge. Perianal fistulas are traditionally described using the Parks classification based on their relationship to the external and internal anal sphincters. Traditional therapy for perianal fistulas focuses on antibiotics such as metronidazole or ciprofloxacin. However, medical management has expanded over the years to include immunomodulators and, most recently, biologic agents. Newer techniques such as intrafistulous biologic injections are also being explored as potentially effective treatments for patients with fistulizing disease. Here, in the first of a 2-part series on perianal fistulas in patients with Crohn's disease, we discuss the anatomy and classification of perianal fistulas as well as current medical therapies, including antibiotics, immunomodulators, biologic agents, and novel therapeutic agents. The second part of the series will focus on the surgical modalities that are available for patients with perianal fistulas in addition to novel endoscopic techniques and future therapies that are being investigated for the treatment of fistulizing Crohn's disease.
Indexed as
Identifiers
30302062PMC6170888W2896919713What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.