ArticleNature communications2018
Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling.
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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47 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
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Authors and funding
27 authors at 2 institutions in 2 countries.
Yong ZhangDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.ORCID http://orcid.org/0000-0002-8754-8938
Lihua SunDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Lina XuanDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Zhenwei PanDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Xueling HuDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Hongyu LiuDepartment of cardiovascular surgery, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Yunlong BaiDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Lei JiaoDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Zhange LiDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Lina CuiDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Xiaoxue WangDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Siqi WangDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Tingting YuDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Bingbing FengDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Ying GuoDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Zonghong LiuDepartment of cardiovascular surgery, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Weixin MengDepartment of cardiovascular surgery, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Hequn RenDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Jiyuan ZhuDepartment of pathology, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Xuyun ZhaoDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Chao YangDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Ying ZhangDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Chaoqian XuMu Danjiang Medical University Mu Danjiang, Heilongjiang, 157011, P.R. China.
Zhiguo WangDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Yanjie LuDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China.
Hongli ShanDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China. shanhongli@ems.hrbmu.edu.cn.
Baofeng YangDepartment of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, P.R. China. yangbf@ems.hrbmu.edu.cn.ORCID http://orcid.org/0000-0002-0125-1608
Harbin Medical University · CNMudanjiang Medical University · CN
Funding
National Natural Science Foundation of China (National Science Foundation of China) 81421063
Abstract
Long non-coding RNAs (lncRNAs) have emerged as a new class of gene expression regulators playing key roles in many biological and pathophysiological processes. Here, we identify cardiac conduction regulatory RNA (CCRR) as an antiarrhythmic lncRNA. CCRR is downregulated in a mouse model of heart failure (HF) and in patients with HF, and this downregulation slows cardiac conduction and enhances arrhythmogenicity. Moreover, CCRR silencing induces arrhythmias in healthy mice. CCRR overexpression eliminates these detrimental alterations. HF or CCRR knockdown causes destruction of intercalated discs and gap junctions to slow longitudinal cardiac conduction. CCRR overexpression improves cardiac conduction by blocking endocytic trafficking of connexin43 (Cx43) to prevent its degradation via binding to Cx43-interacting protein CIP85, whereas CCRR silence does the opposite. We identified the functional domain of CCRR, which can reproduce the functional roles and pertinent molecular events of full-length CCRR. Our study suggests CCRR replacement a potential therapeutic approach for pathological arrhythmias.
Indexed as
AnimalsArrhythmias, CardiacConnexin 43Excitation Contraction CouplingExtracellular SpaceGap JunctionsGene Expression RegulationGene Knockdown TechniquesHeart Conduction SystemHeart FailureHumansMaleMice, Inbred C57BLModels, BiologicalMyocardiumrab GTP-Binding ProteinsCIP85 protein, mouseConnexin 43rab GTP-Binding ProteinsRNA, Long Noncoding
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