ArticleScientific reports2018
Age-Related Measurements of the Myelin Water Fraction derived from 3D multi-echo GRASE reflect Myelin Content of the Cerebral White Matter.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 64 citations in OpenAlex.
- Detection of Lipid-Mediated Diffused Pathological Changes in Multiple Sclerosis.Research square · 2026Article
- MRI-Based Quantitative Assessment of Normal-Appearing White and Gray Matter Demyelination in Multiple Sclerosis, Parkinson's Disease, Long COVID, and Normal Aging.Biomedicines · 2026Article
- Input Layer Regularization and Automated Regularization Hyperparameter Tuning for Myelin Water Estimation Using Deep Learning.NMR in biomedicine · 2026Article
- Ageing and remyelination failure in people with multiple sclerosis.Brain : a journal of neurology · 2026Review
- Decoding Brain Development and Aging: Pioneering Insights From MRI Techniques.Investigative radiology · 2025Review
- Global and Regional Sex-Related Differences, Asymmetry, and Peak Age of Brain Myelination in Healthy Adults.Journal of clinical medicine · 2024Article
- The Impact of HIV on Early Brain Aging-A Pathophysiological (Re)View.Journal of clinical medicine · 2024Review
- Neuronal microstructural changes in the human brain are associated with neurocognitive aging.bioRxiv : the preprint server for biology · 2024Article
- Article
- 3D MR fingerprinting-derived myelin water fraction characterizing brain development and leukodystrophy.Journal of translational medicine · 2023Article
- Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status.Brain : a journal of neurology · 2023Review
- Increased oligodendrogenesis and myelination in the subventricular zone of aged mice and gray mouse lemurs.Stem cell reports · 2023Article
- Association of brain tissue cerebrospinal fluid fraction with age in healthy cognitively normal adults.Frontiers in aging neuroscience · 2023Article
- Sex moderates the association between age and myelin water fraction in the cingulum and fornix among older adults without dementia.Frontiers in aging neuroscience · 2023Article
- Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults.Cerebral circulation - cognition and behavior · 2023Article
- Symmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter.Frontiers in neurology · 2023Article
- Insights into human cerebral white matter maturation and degeneration across the adult lifespan.NeuroImage · 2022Article
- Prediction of brain age using quantitative parameters of synthetic magnetic resonance imaging.Frontiers in aging neuroscience · 2022Article
- Brain aging mechanisms with mechanical manifestations.Mechanisms of ageing and development · 2021Review
- Investigation of the association between cerebral iron content and myelin content in normative aging using quantitative magnetic resonance neuroimaging.NeuroImage · 2021Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
Myelin Water Fraction (MWF) measurements derived from quantitative Myelin Water Imaging (MWI) may detect demyelinating changes of the cerebral white matter (WM) microstructure. Here, we investigated age-related alterations of the MWF in normal aging brains of healthy volunteers utilizing two fast and clinically feasible 3D gradient and spin echo (GRASE) MWI sequences with 3 mm and 5 mm isotropic voxel size. In 45 healthy subjects (age range: 18-79 years), distinct regions of interest (ROI) were defined in the cerebral WM including corticospinal tracts. For the 3 mm sequence, significant correlations of the mean MWF with age were found for most ROIs (r < -0.8 for WM ROIs; r = -0.55 for splenium of corpus callosum; r = -0.75 for genu of corpus callosum; p < 0.001 for all ROIs). Similar correlations with age were found for the ROIs of the 5 mm sequence. No significant correlations were found for the corticospinal tract and the occipital WM (p > 0.05). Mean MWF values obtained from the 3 mm and 5 mm sequences were strongly comparable. The applied 3D GRASE MWI sequences were found to be sensitive for age-dependent myelin changes of the cerebral WM microstructure. The reported MWF values might be of substantial use as reference for further investigations in patient studies.
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