Evidence map›Paper›PMID 30301877›Full record

ArticleBlood cancer journal2018

Loss of TNFAIP3 enhances MYD88

Kerstin Wenzl, Michelle K Manske, Vivekananda Sarangi, Yan W Asmann, Patricia T Greipp, Hanna R Schoon, Esteban Braggio, Matthew J Maurer, Andrew L Feldman, Thomas E Witzig and 4 more

Open access · goldAbstract read
In one paragraph

Article in Blood cancer journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
  2. Decoding IGLL5 Mutation-Mediated BCR Signaling: A Novel Mechanism of CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Iranian journal of basic medical sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Kerstin WenzlDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Michelle K ManskeDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Vivekananda SarangiDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Yan W AsmannDepartment of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA.
Patricia T GreippGenomics Laboratory, Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Hanna R SchoonDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Esteban BraggioDivision of Hematology, Mayo Clinic, Phoenix, AZ, USA.
Matthew J MaurerDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-1867-0526
Andrew L FeldmanDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-5009-4808
Thomas E WitzigDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Susan L SlagerDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Stephen M AnsellDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
James R CerhanDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-7482-178X
Anne J NovakDivision of Hematology, Mayo Clinic, Rochester, MN, USA. Novak.Anne@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic in Florida · USMayo Clinic · USWinnMed · US

Funding

The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI WEINER, GEORGE J. · 2002 to 2021
$45.7M
Genetic Predictors of Early Clinical Failure in Diffuse Large B Cell LymphomaR01CA212162 · NCI · MAYO CLINIC ROCHESTER · PI CERHAN, JAMES R, NOVAK, ANNE JOSEPHINE · 2017 to 2021
$3.3M
NCI NIH HHS P50 CA097274NCI NIH HHS R01 CA212162
6 · The paper itself

Abstract

MYD88 mutations are one of the most recurrent mutations in hematologic malignancies. However, recent mouse models suggest that MYD88

Indexed as

Gene Expression Regulation, NeoplasticMutationSignal TransductionBiomarkersCell LineCell ProliferationCytokinesDNA Copy Number VariationsDrug Resistance, NeoplasmExome SequencingGene Knockdown TechniquesHumansJanus KinasesLymphoma, Non-HodgkinModels, BiologicalMyeloid Differentiation Factor 88BiomarkersCytokinesJanus KinasesMyeloid Differentiation Factor 88NF-kappa BSTAT Transcription FactorsTNFAIP3 protein, humanTumor Necrosis Factor alpha-Induced Protein 3

Identifiers

PMID30301877
PMCPMC6177394
OpenAlexW2896693618

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.