Evidence map›Paper›PMID 30301870›Full record

ArticleThe Journal of general physiology2018

Kinetic properties of persistent Na

Tadashi Yamanishi, Hidehiko Koizumi, Marco A Navarro, Lorin S Milescu, Jeffrey C Smith

Open access · bronzeAbstract readValidation Study
In one paragraph

Article in The Journal of general physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. A Reinterpretation of the Relationship between Persistent and Resurgent Sodium Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Role of NaCell reports · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Somatostatin-Positive Interneurons Contribute to Seizures inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Tadashi YamanishiCellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
Hidehiko KoizumiCellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-7747-3434
Marco A NavarroDivision of Biological Sciences, University of Missouri, Columbia, MO.ORCID 0000-0002-2443-102X
Lorin S MilescuDivision of Biological Sciences, University of Missouri, Columbia, MO milescul@missouri.edu.ORCID 0000-0002-3177-7010
Jeffrey C SmithCellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD smithj2@ninds.nih.gov.ORCID 0000-0002-7676-4643
National Institutes of Health · USUniversity of Missouri · US

Funding

Neural Mechanisms Controlling Breathing In MammalsZIANS002899 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SMITH, JEFFREY C · 2009 to 2023
$21.1M
MINORITY BIOMEDICAL RESEARCHERS TRAINING INITIATIVER25GM056901 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI HANNINK, MARK · 1999 to 2019
$8.4M
NIGMS NIH HHS R25 GM056901
6 · The paper itself

Abstract

The rhythmic pattern of breathing depends on the pre-Bötzinger complex (preBötC) in the brainstem, a vital circuit that contains a population of neurons with intrinsic oscillatory bursting behavior. Here, we investigate the specific kinetic properties that enable voltage-gated sodium channels to establish oscillatory bursting in preBötC inspiratory neurons, which exhibit an unusually large persistent Na

Indexed as

Action PotentialsModels, NeurologicalAnimalsComputer SimulationFemaleInhalationKineticsMaleNeuronsPatch-Clamp TechniquesRats, Sprague-DawleyRespiratory CenterSodiumSodium

Identifiers

PMID30301870
PMCPMC6219691
OpenAlexW2896549309

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.