Evidence map›Paper›PMID 30301850›Full record

ArticlemBio2018

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis.

Caroline S Foo, Andréanne Lupien, Maryline Kienle, Anthony Vocat, Andrej Benjak, Raphael Sommer, Dirk A Lamprecht, Adrie J C Steyn, Kevin Pethe, Jérémie Piton and 2 more

Abstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. The Mycobacterial cyt-Journal of medicinal chemistry · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Structure-Activity Relationship Study of Benzamides asACS medicinal chemistry letters · 2025
    Article
  7. New Triazolopyrimidines with Improved Activity againstACS medicinal chemistry letters · 2025
    Article
  8. Article
  9. ACS infectious diseases · 2025
    Article
  10. Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research.Angewandte Chemie (International ed. in English) · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. MedComm · 2023
    Review
  17. Article
  18. Target Identification in Anti-Tuberculosis Drug Discovery.International journal of molecular sciences · 2023
    Review
  19. Molecular Mechanisms of MmpL3 Function and Inhibition.Microbial drug resistance (Larchmont, N.Y.) · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Caroline S Foo *Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0002-6380-4917
Andréanne Lupien *Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Maryline KienleDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Zurich, Switzerland.
Anthony VocatGlobal Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Andrej BenjakGlobal Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0003-4522-6575
Raphael SommerGlobal Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Dirk A LamprechtAfrica Health Research Institute, Durban, South Africa.
Adrie J C SteynAfrica Health Research Institute, Durban, South Africa.
Kevin PetheLee Kong Chian School of Medicine and School of Biological Sciences, Nanyang Technological University, Singapore.
Jérémie PitonGlobal Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Karl-Heinz AltmannDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Zurich, Switzerland.
Stewart T ColeGlobal Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland stewart.cole@epfl.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New drugs are needed to control the current tuberculosis (TB) pandemic caused by infection with

Indexed as

AmidesAnimalsAntitubercular AgentsBacterial ProteinsCell LineElectron Transport Complex IIIFemaleHumansMacrophagesMiceMice, Inbred BALB CMicrobial Sensitivity TestsMycobacterium tuberculosisPiperazinesTuberculosisAmidesAntitubercular AgentsBacterial ProteinsElectron Transport Complex IIIPiperazinescytochrome bc1 oxidasecytochrome bd oxidasemycobacterial diseasesmycobacterial respirationQcrB inhibitortuberculosis

Identifiers

PMID30301850
PMCPMC6178619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.