ArticleThorax2019
Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation.
Article in Thorax, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Challenges and Recommendations for Integrating Circadian Medicine in Critical Care: A Roadmap.Chest · 2026Guideline
- Outcomes of lung transplantation surgery performed at night.JTCVS open · 2026Article
- Time of day of cardiac surgery and postoperative outcomes in the UK: a secondary analysis of linked national datasets.Anaesthesia · 2026Article
- Adrenaline restores Bmal1 transcriptional rhythms dampened by SARS-CoV-2 infection in Cthrc1-positive pulmonary fibroblasts derived from the Nile grass rat.Scientific reports · 2026Article
- Time as a Therapeutic Ally: The Promise of Long-Term Solid Organ and Tissue Perfusion.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
- Article
- Circadian immune system in solid organ transplantation: a review article.Frontiers in immunology · 2025Review
- Circadian rhythms in solid organ transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Review
- Is timing everything? Examining operative time in lung transplants from 2006 to 2023.JHLT open · 2024Article
- Controlled Hypothermic Storage for Lung Preservation: Leaving the Ice Age Behind.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Lung transplantation following controlled hypothermic storage with a portable lung preservation device: first multicenter European experience.Frontiers in cardiovascular medicine · 2024Article
- Circadian regulation of pulmonary disease: the importance of timing.Clinical science (London, England : 1979) · 2023Review
- Primary graft dysfunction following lung transplantation: From pathogenesis to future frontiers.World journal of transplantation · 2023Review
- ClinCirc identifies alterations of the circadian peripheral oscillator in critical care patients.The Journal of clinical investigation · 2023Article
- Impact of Nighttime Lung Transplantation on Outcomes and Costs.The Annals of thoracic surgery · 2021Article
- Day-Time Declamping Is Associated with Better Outcomes in Kidney Transplantation: The Circarein Study.Journal of clinical medicine · 2021Article
- The clock geneProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
- The circadian clock protein REVERBα inhibits pulmonary fibrosis development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The importance of circadian factors in managing patients is poorly understood. We present two retrospective cohort studies showing that lungs reperfused between 4 and 8 AM have a higher incidence (OR 1.12; 95% CI 1.03 to 1.21; p=0.01) of primary graft dysfunction (PGD) in the first 72 hours after transplantation. Cooling of the donor lung, occurring during organ preservation, shifts the donor circadian clock causing desynchrony with the recipient. The clock protein REV-ERBα directly regulates PGD biomarkers explaining this circadian regulation while also allowing them to be manipulated with synthetic REV-ERB ligands.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.