Evidence map›Paper›PMID 30301782›Full record

ArticleJournal of cell science2018

The AAA ATPase Afg1 preserves mitochondrial fidelity and cellular health by maintaining mitochondrial matrix proteostasis.

Edward M Germany, Nataliya Zahayko, Mason L Huebsch, Jennifer L Fox, Veena Prahlad, Oleh Khalimonchuk

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Screening and In Silico Analyses of the YeastFoods (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Edward M GermanyDepartment of Biochemistry, Nebraska Redox Biology Center, University of Nebraska, Lincoln, NE 68588, USA.
Nataliya ZahaykoDepartment of Biochemistry, Nebraska Redox Biology Center, University of Nebraska, Lincoln, NE 68588, USA.
Mason L HuebschDepartment of Chemistry and Biochemistry, College of Charleston, Charleston, SC 29424, USA.
Jennifer L FoxDepartment of Chemistry and Biochemistry, College of Charleston, Charleston, SC 29424, USA okhalimonchuk2@unl.edu foxjl@cofc.edu.
Veena PrahladDepartment of Biology, Aging Mind and Brain Initiative, University of Iowa, Iowa City, IA 52242, USA.
Oleh KhalimonchukDepartment of Biochemistry, Nebraska Redox Biology Center, University of Nebraska, Lincoln, NE 68588, USA okhalimonchuk2@unl.edu foxjl@cofc.edu.ORCID 0000-0002-3972-8678
University of Nebraska–Lincoln · USCollege of Charleston · USUniversity of Iowa · US

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
Supplement for South Carolina BRIN - 1P20 RR16461P20RR016461 · NCRR · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI DEAVOR, JAMES · 2001 to 2011
$32.3M
Redox Biology CenterP30GM103335 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI BECKER, DONALD F · 2012 to 2016
$4.3M
Uncovering how serotonergic signaling non-autonomously regulates protein homeostasisR01AG050653 · NIA · UNIVERSITY OF IOWA · PI PRAHLAD, VEENA · 2016 to 2020
$1.5M
A Conserved Metalloprotease Required for Mitochondrial Maintenance and ProtectionR01GM108975 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI KHALIMONCHUK, OLEH · 2014 to 2018
$1.4M
Molecular Mechanisms of DiseaseT32GM107001 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI BECKER, DONALD F, BLACK, PAUL N. · 2015 to 2019
$1.0M
Uncovering non-autonomous mechanisms of control over translational attenuation during heat shock in the metazoan C. elegansR21NS097942 · NINDS · UNIVERSITY OF IOWA · PI PRAHLAD, VEENA · 2016 to 2017
$375k
Howard Hughes Medical Institute 52007537NCRR NIH HHS P20 RR016461NIA NIH HHS R01 AG050653NIGMS NIH HHS P20 GM103499NIGMS NIH HHS P30 GM103335NIGMS NIH HHS R01 GM108975NIGMS NIH HHS T32 GM107001NINDS NIH HHS R21 NS097942
6 · The paper itself

Abstract

Mitochondrial functions are critical for cellular physiology; therefore, several conserved mechanisms are in place to maintain the functional integrity of mitochondria. However, many of the molecular details and components involved in ensuring mitochondrial fidelity remain obscure. Here, we identify a novel role for the conserved mitochondrial AAA ATPase Afg1 in mediating mitochondrial protein homeostasis during aging and in response to various cellular challenges.

Indexed as

Adenosine TriphosphatasesAnimalsATPases Associated with Diverse Cellular ActivitiesCaenorhabditis elegansCaenorhabditis elegans ProteinsMitochondriaMitochondrial ProteinsProteostasisSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAdenosine TriphosphatasesAfg1 protein, S cerevisiaeATPases Associated with Diverse Cellular ActivitiesCaenorhabditis elegans ProteinsMitochondrial ProteinsSaccharomyces cerevisiae ProteinsC. elegansLACE-1MitochondriaMitochondrial fidelityProtein homeostasisYeast

Identifiers

PMID30301782
PMCPMC6262775
OpenAlexW2896467715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.