ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Ipsilesional Motor Cortex Plasticity Participates in Spontaneous Hindlimb Recovery after Lateral Hemisection of the Thoracic Spinal Cord in the Rat.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 54 citations in OpenAlex.
- Neural Excitation-Inhibition Imbalance in Cervical Spondylotic Myelopathy.Communications medicine · 2026Article
- Recovery of Motor Function via Intraspinal Detour Circuits following Unilateral Spinal Cord Injury.European neurology · 2026Article
- Sensory Deficits in Mice with Lateral Spinal Cord Hemisection Mimic the Brown-Séquard Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Combining cortical and spinal stimulation maximizes the improvement of gait after spinal cord injury.iScience · 2025Article
- Article
- Resveratrol and Exercise Produce Recovered Ankle and Metatarsus Joint Movements after Penetrating Lesion in Hippocampus in Male Rats.Brain sciences · 2024Article
- Longitudinal Imaging of Injured Spinal Cord Myelin and White Matter with 3D Ultrashort Echo Time Magnetization Transfer (UTE-MT) and Diffusion MRI.Journal of imaging · 2024Article
- Stage-dependent role of interhemispheric pathway for motor recovery in primates.Nature communications · 2024Article
- Flexible circumferential bioelectronics to enable 360-degree recording and stimulation of the spinal cord.Science advances · 2024Article
- Functional plasticity of glutamatergic neurons of medullary reticular nuclei after spinal cord injury in mice.Nature communications · 2024Article
- Combined effect of Cerium oxide nanoparticles loaded scaffold and photobiomodulation therapy on pain and neuronal regeneration following spinal cord injury: an experimental study.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Article
- Article
- Autonomous optimization of neuroprosthetic stimulation parameters that drive the motor cortex and spinal cord outputs in rats and monkeys.Cell reports. Medicine · 2023Article
- Functional contribution of mesencephalic locomotor region nuclei to locomotor recovery after spinal cord injury.Cell reports. Medicine · 2023Article
- Complex forelimb movements and cortical topography evoked by intracortical microstimulation in male and female mice.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neurovascular Unit Compensation from Adjacent Level May Contribute to Spontaneous Functional Recovery in Experimental Cervical Spondylotic Myelopathy.International journal of molecular sciences · 2023Article
- Changes in operation of postural networks in rabbits with postural functions recovered after lateral hemisection of the spinal cord.The Journal of physiology · 2023Article
- 5-Fluorouracil reduces the fibrotic scar via inhibiting matrix metalloproteinase 9 and stabilizing microtubules after spinal cord injury.CNS neuroscience & therapeutics · 2022Article
- Targeting the motor cortex to restore walking after incomplete spinal cord injury.Neural regeneration research · 2022Article
- NT3 treatment alters spinal cord injury-induced changes in the gray matter volume of rhesus monkey cortex.Scientific reports · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
After an incomplete spinal cord injury (SCI) spontaneous motor recovery can occur in mammals, but the underlying neural substrates remain poorly understood. The motor cortex is crucial for skilled motor learning and the voluntary control of movement and is known to reorganize after cortical injury to promote recovery. Motor cortex plasticity has also been shown to parallel the recovery of forelimb function after cervical SCI, but whether cortical plasticity participates in hindlimb recovery after SCI remains unresolved. Using intracortical microstimulation (ICMS) mapping, behavioral and cortical inactivation techniques in the female Long-Evans rat, we evaluated the spontaneous cortical mechanisms of hindlimb motor recovery 1-5 weeks after lateral hemisection of the thoracic (T8) spinal cord that ablated the crossed corticospinal tract (CST) from the contralesional motor cortex while sparing the majority of the CST from the ipsilesional motor cortex. Hemisection initially impaired hindlimb motor function bilaterally but significant recovery occurred during the first 3 weeks. ICMS revealed time-dependent changes in motor cortex organization, characterized by a chronic abolishment of hindlimb motor representation in the contralesional motor cortex and the development of transient bilateral hindlimb representation in the ipsilesional motor cortex 3 weeks after hemisection, when significant behavioral recovery occurred. Consistently, reversible inactivation of the ipsilesional, but not the contralesional motor cortex, during skilled ladder walking 3 weeks after hemisection reinstated deficits in both hindlimbs. These findings indicate that the ipsilesional motor cortex transiently reorganizes after lateral hemisection of the thoracic spinal cord to support recovery of hindlimb motor function.
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