ReviewDental materials : official publication of the Academy of Dental Materials2019
Biostable, antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions.
Review in Dental materials : official publication of the Academy of Dental Materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Antimicrobial potential of bioactive resin composites in caries management: a systematic review ofFrontiers in oral health · 2025Pooled it
- Evaluation of a long-term antimicrobial dental adhesive via in vitro biodegradation and in vivo rodent secondary caries models.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- Article
- Antibacterial effects of bioactive restorative dental materials on Streptococcus mutans: An in vitro study using the direct contact test.The Saudi dental journal · 2025Article
- Durable Dentin Bonding with Multifunctional Methacrylated Proanthocyanidins.Journal of dental research · 2025Article
- Effects of Grape Seed Extract-Modified Etchants on Collagenolytic Activity, Interface Formation, and Bonding Longevity of Adhesive-Dentin Interfaces.Materials (Basel, Switzerland) · 2025Article
- Synergistic effects of bacteria, enzymes, and cyclic mechanical stresses on the bond strength of composite restorations.Biomaterials advances · 2025Article
- Assessment of Surface Roughness, Color, and Bonding Efficacy: Self-Adhesive vs. Conventional Flowable Resin.Polymers · 2024Article
- Engineering Interfacial Integrity with Hydrolytic-Resistant, Self-Reinforcing Dentin Adhesive.International journal of molecular sciences · 2024Article
- Enhancing Dental Material Performance: Tung Oil-Infused Polyurea Microcapsule Coatings for Self-Healing and Antimicrobial Applications.Polymers · 2024Article
- Synergistic enhancement of hydrophobic dental adhesives: autonomous strengthening, polymerization kinetics, and hydrolytic resistance.Frontiers in dental medicine · 2024Article
- Study on the mechanical and aging properties of an antibacterial composite resin loaded with fluoride-doped nano-zirconia fillers.Frontiers in bioengineering and biotechnology · 2024Article
- Synthesis of Pore-Size-Tunable Porous Silica Particles and Their Effects on Dental Resin Composites.Biomolecules · 2023Article
- Effects of Bio-Aging on Mechanical Properties and Microbial Behavior of Different Resin Composites.Biomolecules · 2023Article
- Smart dental materials for antimicrobial applications.Bioactive materials · 2023Article
- The potential of salivary albumin to degrade composite resin.Acta odontologica latinoamericana : AOL · 2023Article
- Degradation and Failure Phenomena at the Dentin Bonding Interface.Biomedicines · 2023Review
- Enhancing dentin bonding quality through Acetone wet-bonding technique: a promising approach.Frontiers in bioengineering and biotechnology · 2023Article
- Bioceramic micro-fillers reinforce antibiofilm and remineralization properties of clear aligner attachment materials.Frontiers in bioengineering and biotechnology · 2023Article
- Biodegradation of Dental Resin-Based Composite-A Potential Factor Affecting the Bonding Effect: A Narrative Review.Biomedicines · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectivesDespite decades of development and their status as the restorative material of choice for dentists, resin composite restoratives and adhesives exhibit a number of shortcomings that limit their long-term survival in the oral cavity. Herein we review past and current work to understand these challenges and approaches to improve dental materials and extend restoration service life.
methodsPeer-reviewed work from a number of researchers as well as our own are summarized and analyzed. We also include yet-unpublished work of our own. Challenges to dental materials, methods to assess new materials, and recent material improvements and research directions are presented.
resultsMechanical stress, host- and bacterial-biodegradation, and secondary caries formation all contribute to restoration failure. In particular, several host- and bacterial-derived enzymes degrade the resin and collagen components of the hybrid layer, expanding the marginal gap and increasing access to bacteria and saliva. Furthermore, the virulence of cariogenic bacteria is up-regulated by resin biodegradation by-products, creating a positive feedback loop that increases biodegradation. These factors work synergistically to degrade the restoration margin, leading to secondary caries and restoration failure. Significant progress has been made to produce hydrolytically stable resins to resist biodegradation, as well as antimicrobial materials to reduce bacterial load around the restoration. Ideally, these two approaches should be combined in a holistic approach to restoration preservation. SIGNIFICANCE: The oral cavity is a complex environment that poses an array of challenges to long-term material success; materials testing conditions should be comprehensive and closely mimic pathogenic oral conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.