Evidence map›Paper›PMID 30301592›Full record

ReviewTrends in immunology2018

Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance.

Dana K Shaw, Ann T Tate, David S Schneider, Elena A Levashina, Jonathan C Kagan, Utpal Pal, Erol Fikrig, Joao H F Pedra

Open access · greenAbstract readReview
In one paragraph

Review in Trends in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
  3. ATF6 enables pathogen infection in ticks by inducingProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Genomic Insights into Vector-Pathogen Adaptation inPathogens (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Trained Immunity inFrontiers in microbiology · 2021
    Article
  20. Lyme Disease in Humans.Current issues in molecular biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 2 countries.

Dana K ShawDepartment of Veterinary Microbiology and Pathology, Washington State, Pullman, WA, USA. Electronic address: dana.shaw@wsu.edu.
Ann T TateDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA. Electronic address: a.tate@vanderbilt.edu.
David S SchneiderDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
Elena A LevashinaVector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.
Jonathan C KaganDivision of Gastroenterology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Utpal PalDepartment of Veterinary Medicine, University of Maryland, College Park, MD, USA.
Erol FikrigSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Joao H F PedraDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: jpedra@som.umaryland.edu.
Boston Children's Hospital · USHoward Hughes Medical Institute · USMax Planck Institute for Infection Biology · DEStanford University · USUniversity of Maryland, Baltimore · USUniversity of Maryland, College Park · USVanderbilt University · USWashington State University · US

Funding

Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig, UTPAL PAL · 2018 to 2026
$13.5M
Development of Paratransgenic Ticks for Disease ControlR01AI049424 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MUNDERLOH, ULRIKE GERTRUD · 2002 to 2022
$6.9M
Ubiquitylation and Rickettsial Colonization of a Tick VectorR01AI116523 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2016 to 2025
$6.2M
Tick Saliva and Pathogen TransmissionR01AI134696 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Joao Pedra · 2018 to 2026
$5.1M
The role of tick gut microbiota in Borrelia burgdorferi transmission to miceR01AI126033 · NIAID · YALE UNIVERSITY · PI FIKRIG, EROL, NARASIMHAN, SUKANYA · 2017 to 2020
$1.7M
TICK-PATHOGEN INTERFACE: INVESTIGATING CROSSTALK BETWEEN STRESS RESPONSES AND IMMUNITYR21AI139772 · NIAID · WASHINGTON STATE UNIVERSITY · PI SHAW, DANA KATHLEEN · 2018 to 2019
$421k
Howard Hughes Medical InstituteNIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI049424NIAID NIH HHS R01 AI116523NIAID NIH HHS R01 AI126033NIAID NIH HHS R01 AI134696NIAID NIH HHS R21 AI139772
6 · The paper itself

Abstract

Recent scientific breakthroughs have significantly expanded our understanding of arthropod vector immunity. Insights in the laboratory have demonstrated how the immune system provides resistance to infection, and in what manner innate defenses protect against a microbial assault. Less understood, however, is the effect of biotic and abiotic factors on microbial-vector interactions and the impact of the immune system on arthropod populations in nature. Furthermore, the influence of genetic plasticity on the immune response against vector-borne pathogens remains mostly elusive. Herein, we discuss evolutionary forces that shape arthropod vector immunity. We focus on resistance, pathogenicity and tolerance to infection. We posit that novel scientific paradigms should emerge when molecular immunologists and evolutionary ecologists work together.

Indexed as

AnimalsArthropodsArthropod VectorsBiological EvolutionEcologyHumansImmune ToleranceImmunityMammalsSignal Transduction

Identifiers

PMID30301592
PMCPMC6218297
OpenAlexW2895072165

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.