Evidence map›Paper›PMID 30301473›Full record

Trial reportLipids in health and disease2018

Exercise intervention alters HDL subclass distribution and function in obese women.

Nicholas J Woudberg, Amy E Mendham, Arieh A Katz, Julia H Goedecke, Sandrine Lecour

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 6 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  4. The Benefits of Physical Activity for People with Obesity, Independent of Weight Loss: A Systematic Review.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nicholas J WoudbergHatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. nicholaswoudberg@gmail.com.
Amy E MendhamNon-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.
Arieh A KatzUCT Research Unit for Receptor biology, Department of Integrative Biomedical Sciences and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Julia H GoedeckeNon-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.
Sandrine LecourHatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZASouth African Medical Research Council · ZA

Funding

National Research Foundation 93577
6 · The paper itself

Abstract

backgroundObesity is associated with a change in high-density lipoprotein (HDL) function and subclass. Exercise training reduces cardiovascular risk in obese patients. We aimed to explore the effect of an exercise training stimulus on HDL functionality and subclass in obese women.

methodsThirty-two obese black South African women were randomly assigned to exercise (combined aerobic and resistance exercise) or control (no exercise) conditions for 12-weeks. Pre- and post-testing included venous blood sampling for analysis of lipid profile and HDL functionality, by measuring cellular cholesterol efflux capacity, reduction in endothelial vascular cell adhesion molecule (VCAM) expression (anti-inflammatory function), paraoxonase (PON) (antioxidative function) and platelet activating factor acetylhydrolase (PAF-AH) activities (anti-thrombotic function). PON-1 and PAF-AH expression were determined in serum and in isolated HDL using Western blotting. Levels of large, intermediate and small HDL subclasses were measured using the Lipoprint® system.

resultsExercise training resulted in a decrease in body mass index (- 1.0 ± 0.5% vs + 1.2 ± 0.6%, p = 0.010), PON activity (- 8.7 ± 2.4% vs + 1.1 ± 3.0%, p = 0.021), PAF-AH serum expression (- 22.1 ± 8.0% vs + 16.9 ± 9.8, p = 0.002), and the distribution of small HDL subclasses (- 10.1 ± 5.4% vs + 15.7 ± 6.6%, p = 0.004) compared to controls. Exercise did not alter HDL cellular cholesterol efflux capacity and anti-inflammatory function.

conclusionsThese results demonstrate the potential for exercise training to modify HDL subclass distribution and HDL function in obese women.

trial registrationClinical trials number: PACTR201711002789113 .

Indexed as

Exercise Therapy1-Alkyl-2-acetylglycerophosphocholine EsteraseAdultAryldialkylphosphataseBlack PeopleFemaleHumansLipoproteins, HDLObesityVascular Cell Adhesion Molecule-1Young Adult1-Alkyl-2-acetylglycerophosphocholine EsteraseAryldialkylphosphataseLipoproteins, HDLPLA2G7 protein, humanVascular Cell Adhesion Molecule-1Anti-inflammatoryAntioxidativeCholesterol effluxExercise interventionHDL structureHDL subclassObesity

Identifiers

PMID30301473
PMCPMC6178267
OpenAlexW2896964365

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.