Evidence map›Paper›PMID 30301302›Full record

ArticlePsychiatry investigation2018

Effects of 5HT1A Activation on Depression Profile Following 5-HT Depletion in Rats Lacking Social Attachment Since Weanling.

Kuo-Jung Chang, Yu-Jung Chen, Jing-Yi Chung, Chen-Cheng Lin, Yia-Ping Liu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kuo-Jung ChangDepartment of Psychiatry, Hualien Armed Forces General Hospital, Hualien, Taiwan.
Yu-Jung ChenDepartment of Psychiatry, Hualien Armed Forces General Hospital, Hualien, Taiwan.
Jing-Yi ChungLaboratory of Cognitive Neuroscience, Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan.
Chen-Cheng LinLaboratory of Cognitive Neuroscience, Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan.
Yia-Ping LiuLaboratory of Cognitive Neuroscience, Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan.
National Defense Medical Center · TWHualien Armed Forces General Hospital · TW

Funding

Cheng Hsin General Hospital Foundation CH-NDMC-106-3Cheng Hsin General Hospital Foundation CH-NDMC-107-1Hualien Armed Forces General Hospital 805-C106-03Hualien Armed Forces General Hospital 805-C107-06Ministry of Science and Technology 105-2410-H-016-002-MY2National Defense Medical Center MAB102-83Tri-Service General Hospital TSGH-C106-107
6 · The paper itself

Abstract

objectivePost weanling isolation-reared (IR) rats are featured with depressive phenotype, yet its mechanism is not clearly defined particularly in terms of the involvement of central 5-HT1A receptors. The present study aims to examine the effects of 5HT1A activation on forced swim test (FST) in IR rats following 5-HT depletion.

methodsSocial control (SOC) and IR rats received an intracerebraoventricular (ICV) injection of 5-HT depletion agent, 5,7-DHT. 14 days after the surgery, rats were assessed their performance in FST with or without the challenge with a 5-HT1A agonist, 8-OH-DPAT. Rats were then sacrificed for analyzing their 5-HT tissue levels and the expressions of their 5-HA1A receptors in prefrontal cortex (PFC), hippocampus (HPX), and amygdala (AMY).

results5,7-DHT decreased the tissue concentration of 5-HT in both IR and SOC rats. IR rats were more immobile and less sensitive to the lesion-induced immobility, however this effect was reversed by acute challenge of 8-OH-DPAT. 5,7-DHT lesion increased the expression of PFC 5-HT1A receptors.

conclusionThe integrity of central 5-HT system is developmentally crucial for the 5-HT1A-relevant depression profile in rats of social isolation.

Indexed as

5-HT1A receptorsDepressionIsolation-rearingSerotonin

Identifiers

PMID30301302
PMCPMC6212703
OpenAlexW2790440884

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.