ArticlePsychiatry investigation2018
The Relationship between Plasma Oxytocin Levels and Social Anxiety Symptoms.
Article in Psychiatry investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Baseline serum oxytocin and OXTR rs53576 genotype are not predictive of escitalopram response in generalized anxiety disorder.Scientific reports · 2026Article
- The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease.Endocrine reviews · 2025Review
- Effects of systemic oxytocin receptor activation and blockade on risky decision making in female and male rats.Behavioral neuroscience · 2025Article
- OXTR rs2254298 polymorphism influences escitalopram response in Generalized Anxiety Disorder: a sex-specific role for oxytocin signaling.Frontiers in psychiatry · 2025Article
- Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders.Cell & bioscience · 2023Review
- Oxytocin Levels in Children with Separation Anxiety and Their Mothers before and after Treatment.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Association between salivary oxytocin levels and the amygdala and hippocampal volumes.Brain structure & function · 2022Article
- Oxytocin and Vasopressin Levels and Related Factors in Adolescents with Social Phobia and Other Anxiety Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Article
- Is oxytocin a trust hormone? Salivary oxytocin is associated with caution but not with general trust.PloS one · 2022Article
- Salivary Oxytocin Is Negatively Associated With Religious Faith in Japanese Non-Abrahamic People.Frontiers in psychology · 2021Article
- Decreased Plasma Oxytocin Levels in Patients With PTSD.Frontiers in psychology · 2021Article
- Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview.Brain sciences · 2020Review
- Serum oxytocin levels are elevated in body dysmorphic disorder and related to severity of psychopathology.Psychoneuroendocrinology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe pathophysiology of social anxiety disorder (SAD) is not yet well understood, but previous research has suggested that oxytocin is associated with social behavior and may play a role in human anxiety states and anxiety-related traits. The aim of this study was to investigate the possible relationship between social anxiety symptoms and plasma oxytocin levels.
methodsTwenty-three male patients with SAD and 28 healthy male controls participated in this study. All participants were assessed using the Mini International Neuropsychiatric Interview (MINI) and the Liebowitz Social Anxiety Scale (LSAS). Multivariate regression analysis was performed to identify associations between plasma oxytocin levels and SAD.
resultsIn multiple regression models, after controlling for age and years of education, we found that higher oxytocin levels were significantly associated with higher total LSAS scores (R2 =0.157, coefficient=0.145, 95% CI=-0.0005-0.291, p=0.051) and fear subscale scores (R2 =0.134, coefficient=0.083, 95% CI=0.007-0.159, p=0.034) in the SAD group.
conclusionIn this study, increased plasma oxytocin levels were associated with higher social anxiety symptoms among SAD patients, but not among controls. This might be because among SAD patients, higher oxytocin (OT) secretion is an insufficient compensatory attempt to reduce social anxiety symptoms.
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