Evidence map›Paper›PMID 30301277›Full record

ArticleInternational journal of molecular sciences2018

Synthesis and Biological Evaluation of Thalidomide Derivatives as Potential Anti-Psoriasis Agents.

Kai-Wei Tang, Zih-Chan Lin, Yeh-Long Chen, Cherng-Chyi Tzeng, Jia-You Fang, Chih-Hua Tseng

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Anti-Inflammatory Activity of Cyclic Imide Derivatives.Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kai-Wei TangSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. dadaking1107@gmail.com.
Zih-Chan LinGraduate Institute of BioMedical Sciences, Chang Gung University, Taoyuan 333, Taiwan. sevenaurora@gmail.com.
Yeh-Long ChenDepartment of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yeloch@kmu.edu.tw.
Cherng-Chyi TzengDepartment of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan. tzengch@kmu.edu.tw.
Jia-You FangGraduate Institute of BioMedical Sciences, Chang Gung University, Taoyuan 333, Taiwan. fajy@mail.cgu.edu.tw.ORCID 0000-0003-2114-7709
Chih-Hua TsengSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. chihhua@kmu.edu.tw.
Kaohsiung Medical University · TWChang Gung University · TWChang Gung University of Science and Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several thalidomide derivatives were synthesized and evaluated for their anti-inflammatory activity. Introduction of the benzyl group to the parent thalidomide is unfavorable in which 2-(1-benzyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione (

Indexed as

Anti-Inflammatory AgentsCell LineDermatologic AgentsHumansInterleukinsKeratinocytesThalidomideTumor Necrosis Factor-alphaAnti-Inflammatory AgentsDermatologic AgentsInterleukinsThalidomideTumor Necrosis Factor-alphaanti-inflammatoryanti-proliferativepsoriasisthalidomidetumor necrosis factor

Identifiers

PMID30301277
PMCPMC6212999
OpenAlexW2894560719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.