Evidence map›Paper›PMID 30301271›Full record

ReviewInternational journal of molecular sciences2018

Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome.

David L Vollmer, Virginia A West, Edwin D Lephart

Registry-linked trialAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07516756 (Impact of Oral Supplementation of Specific Bioactive Collagen Peptides on Human Skin Physiology), which is not on this map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07516756 nacompletednot on this mapstarted 2024, after this paper: background citation

Impact of Oral Supplementation of Specific Bioactive Collagen Peptides on Human Skin Physiology: A Randomized, Double-Blind, Placebo-Controlled Trial

TypeinterventionalSponsorCollagen Research InstituteRan2024 to 2024Enrolled66ConditionsAge-related Changes in Skin Appearance and PhysiologyArmsPlacebo, Specific Collagen Peptides
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Assessing Anti-Acne PotentialsCurrent drug targets · 2025
    Review
  12. Review
  13. Investigating the Skin Health Benefits ofFood science & nutrition · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David L Vollmer4Life Research, Scientific Research Division, Sandy, UT 84070, USA. Davidv@4Life.com.
Virginia A West4Life Research, Scientific Research Division, Sandy, UT 84070, USA. Virginiap@4Life.com.
Edwin D LephartDepartment of Physiology, Developmental Biology and The Neuroscience Center, Brigham Young University, Provo, UT 84602, USA. Edwin_Lephart@byu.edu.

Funding

Technology Transfer Office (TTO)/Life Sciences College 19-2215
6 · The paper itself

Abstract

The history of cosmetics goes back to early Egyptian times for hygiene and health benefits while the history of topical applications that provide a medicinal treatment to combat dermal aging is relatively new. For example, the term cosmeceutical was first coined by Albert Kligman in 1984 to describe topical products that afford both cosmetic and therapeutic benefits. However, beauty comes from the inside. Therefore, for some time scientists have considered how nutrition reflects healthy skin and the aging process. The more recent link between nutrition and skin aging began in earnest around the year 2000 with the demonstrated increase in peer-reviewed scientific journal reports on this topic that included biochemical and molecular mechanisms of action. Thus, the application of: (a) topical administration from outside into the skin and (b) inside by oral consumption of nutritionals to the outer skin layers is now common place and many journal reports exhibit significant improvement for both on a variety of dermal parameters. Therefore, this review covers, where applicable, the history, chemical structure, and sources such as biological and biomedical properties in the skin along with animal and clinical data on the oral applications of: (a) collagen, (b) ceramide, (c) β-carotene, (d) astaxanthin, (e) coenzyme Q

Indexed as

MicrobiotaAdministration, OralBiological ProductsHumansSkinTrace ElementsVitaminsBiological ProductsTrace ElementsVitaminsastaxanthinceramidecoenzyme Q10collagencolostrumhuman skinmicrobiomeoral applicationsseleniumzincβ-carotene

Identifiers

PMID30301271
PMCPMC6213755

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.