Evidence map›Paper›PMID 30301210›Full record

ArticleMolecules (Basel, Switzerland)2018

Arginine in the FARM and SARM: A Role in Chain-Length Determination for Arginine in the Aspartate-Rich Motifs of Isoprenyl Diphosphate Synthases from

Raimund Nagel, Jill A Thomas, Faith A Adekunle, Francis M Mann, Reuben J Peters

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Structures of Mycobacterium tuberculosis isoprenyl diphosphate synthase Rv2173 in substrate-bound forms.Acta crystallographica. Section F, Structural biology communications · 2025
    Article
  2. Article
  3. Article
  4. Functional Prediction ofInternational journal of molecular sciences · 2022
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Raimund NagelRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA. rnagel@iastate.edu.ORCID 0000-0002-3878-7123
Jill A ThomasRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA. thomas.jillann@gmail.com.
Faith A AdekunleDepartment of Chemistry, University of Wisconsin-Parkside, Kenosha, WI 53141, USA. adeku001@rangers.uwp.edu.
Francis M MannDepartment of Chemistry, University of Wisconsin-Parkside, Kenosha, WI 53141, USA. mannf@uwp.edu.
Reuben J PetersRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA. rjpeters@iastate.edu.ORCID 0000-0003-4691-8477
Iowa State University · USUniversity of Wisconsin–Parkside · US

Funding

Enzymatic formation of the hydrocarbon skeletons underlying diterpenoid diversityR01GM076324 · NIGMS · IOWA STATE UNIVERSITY · PI PETERS, REUBEN JOHN · 2006 to 2019
$3.4M
Deutsche Forschungsgemeinschaft NA 1261/1-2NIGMS NIH HHS GM076324NIGMS NIH HHS R01 GM076324
6 · The paper itself

Abstract

Isoprenyl chains are found in many important metabolites. These are derived from precursors of the appropriate length produced by isoprenyl diphosphate synthases (IDSs). The human pathogen

Indexed as

Amino Acid MotifsAmino Acid SequenceArginineAspartic AcidDiphosphatesDiterpenesGeranyltranstransferaseHumansMutagenesis, Site-DirectedMycobacterium tuberculosisPolyisoprenyl PhosphatesSesquiterpenesTerpenesArginineAspartic AcidDiphosphatesDiterpenesfarnesyl pyrophosphategeranyl diphosphategeranylgeranyl pyrophosphateGeranyltranstransferasePolyisoprenyl PhosphatesSesquiterpenesTerpenesdivalent metal co-factor ligationisoprenoidterpene

Identifiers

PMID30301210
PMCPMC6214179
OpenAlexW2895528942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.