Evidence map›Paper›PMID 30301161›Full record

ArticleBiomolecules2018

A Marine Diterpenoid Modulates the Proteasome Activity in Murine Macrophages Stimulated with LPS.

Yisett González, Deborah Doens, Héctor Cruz, Ricardo Santamaría, Marcelino Gutiérrez, Alejandro Llanes, Patricia L Fernández

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yisett GonzálezCentro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP),Edificio 219, Ciudad del Saber, 0801 Panamá, Panamá. ygonzalez@indicasat.org.pa.ORCID 0000-0002-1623-9484
Deborah DoensCentro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP),Edificio 219, Ciudad del Saber, 0801 Panamá, Panamá. ddoens@gmail.com.
Héctor CruzCentro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP),Edificio 219, Ciudad del Saber, 0801 Panamá, Panamá. hector_cruz@outlook.com.
Ricardo SantamaríaCentro de Biodiversidad y Descubrimiento de Drogas, INDICASAT AIP, Edificio 219, Ciudad del Saber, 0801 Panamá, Panamá. rsantamaria@indicasat.org.pa.
Marcelino GutiérrezCentro de Biodiversidad y Descubrimiento de Drogas, INDICASAT AIP, Edificio 219, Ciudad del Saber, 0801 Panamá, Panamá. mgutierrez@indicasat.org.pa.ORCID 0000-0003-1423-3772
Alejandro LlanesCentro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP),Edificio 219, Ciudad del Saber, 0801 Panamá, Panamá. allanes@indicasat.org.pa.ORCID 0000-0002-6949-2782
Patricia L FernándezCentro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP),Edificio 219, Ciudad del Saber, 0801 Panamá, Panamá. pllanes@indicasat.org.pa.ORCID 0000-0002-0762-0566
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología · PALatin University of Panama · PA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The proteasome is an intracellular complex that degrades damaged or unfolded proteins and participates in the regulation of several processes. The immunoproteasome is a specialized form that is expressed in response to proinflammatory signals and is particularly abundant in immune cells. In a previous work, we found an anti-inflammatory effect in a diterpenoid extracted from the octocoral

Indexed as

AnimalsChymasesDiterpenesHumansLipopolysaccharidesMacrophagesMajor Histocompatibility ComplexMiceMolecular Docking SimulationNF-kappa BNF-KappaB Inhibitor alphaProteasome Endopeptidase ComplexChymasesDiterpenesLipopolysaccharidesNF-kappa BNF-KappaB Inhibitor alphaProteasome Endopeptidase Compleximmunoproteasomemarine diterpenoidproteasome inhibitors

Identifiers

PMID30301161
PMCPMC6315684
OpenAlexW2894711546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.