Evidence map›Paper›PMID 30301147›Full record

ArticleInternational journal of molecular sciences2018

Prostaglandin D₂ Induces Ca

Wataru Suto, Yusuke Ando, Takahiro Hirabayashi, Fumiko Takenoya, Seiji Shioda, Junzo Kamei, Hiroyasu Sakai, Yoshihiko Chiba

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Sustained exposure to prostaglandin DJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Wataru SutoDepartment of Physiology and Molecular Sciences, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. d1502@hoshi.ac.jp.
Yusuke AndoGlobal Research Center for Innovative Life Science, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. p17andoh@hoshi.ac.jp.
Takahiro HirabayashiPeptide Drug Innovation Global Research Center for Innovative Life Science, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. t-hirabayashi@hoshi.ac.jp.
Fumiko TakenoyaDepartment of Physiology and Molecular Sciences, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. kuki@hoshi.ac.jp.
Seiji ShiodaPeptide Drug Innovation Global Research Center for Innovative Life Science, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. shioda@hoshi.ac.jp.
Junzo KameiGlobal Research Center for Innovative Life Science, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. kamei@hoshi.ac.jp.
Hiroyasu SakaiDepartment of Biomolecular Pharmacology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. sakai@hoshi.ac.jp.
Yoshihiko ChibaDepartment of Physiology and Molecular Sciences, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. chiba@hoshi.ac.jp.ORCID 0000-0002-7342-4491
Hoshi University · JP

Funding

Japan Society for the Promotion of Science 15K08248
6 · The paper itself

Abstract

Prostaglandin D₂ (PGD₂) is one of the key lipid mediators of allergic airway inflammation, including bronchial asthma. However, the role of PGD₂ in the pathogenesis of asthma is not fully understood. In the present study, the effect of PGD₂ on smooth muscle contractility of the airways was determined to elucidate its role in the development of airway hyperresponsiveness (AHR). In isolated bronchial smooth muscles (BSMs) of naive mice, application of PGD₂ (10

Indexed as

AnimalsAtropineBronchiBronchial HyperreactivityCalciumCytosolHumansIndolesMaleMiceMice, Inbred BALB CMuscle ContractionMuscle, SmoothPotassiumPrimary Cell CultureProstaglandin D2AtropineCalciumIndolesMK-0524PotassiumProstaglandin D2prostanoid D receptor 1, mouseReceptors, Prostaglandinbronchial smooth muscle hyperresponsivenessCa2+ sensitizationDP1 receptorprostaglandin D2 (PGD2)RhoA

Identifiers

PMID30301147
PMCPMC6213397
OpenAlexW2895772916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.