Evidence map›Paper›PMID 30300984›Full record

ArticleClinical endoscopy2019

Endoscopy Timing in Patients with Acute Upper Gastrointestinal Bleeding.

Gonçalo Alexandrino, Tiago Dias Domingues, Rita Carvalho, Mariana Nuno Costa, Luís Carvalho Lourenço, Jorge Reis

Abstract read
In one paragraph

Article in Clinical endoscopy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Independent predictors of ICU admission, mortality, and intervention requirements in acute upper gastrointestinal bleeding.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025
    Article
  6. Article
  7. The Time of Endoscopy for Nonvariceal Upper Gastrointestinal Bleeding: An Observational Study.The Korean journal of helicobacter and upper gastrointestinal research · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Current Controversies Concerning Capsule Endoscopy.Digestive diseases and sciences · 2019
    Review
  15. Article
  16. Interventional Algorithm in Gastrointestinal Bleeding-An Expert Consensus Multimodal Approach Based on a Multidisciplinary Team.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gonçalo AlexandrinoHospital Professor Doutor Fernando Fonseca, Serviço de Gastrenterologia, Amadora, Portugal.
Tiago Dias DominguesCentro de Estatística e Aplicações da Universidade de Lisboa (CEAUL), Lisbon, Portugal.
Rita CarvalhoHospital Professor Doutor Fernando Fonseca, Serviço de Gastrenterologia, Amadora, Portugal.
Mariana Nuno CostaHospital Professor Doutor Fernando Fonseca, Serviço de Gastrenterologia, Amadora, Portugal.
Luís Carvalho LourençoHospital Professor Doutor Fernando Fonseca, Serviço de Gastrenterologia, Amadora, Portugal.
Jorge ReisHospital Professor Doutor Fernando Fonseca, Serviço de Gastrenterologia, Amadora, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsThe role of very early (≤12 hours) endoscopy in nonvariceal upper gastrointestinal bleeding is controversial. We aimed to compare results of very early and early (12-24 hours) endoscopy in patients with upper gastrointestinal bleeding demonstrating low-risk versus high-risk features and nonvariceal versus variceal bleeding.

methodsThis retrospective study included patients with nonvariceal and variceal upper gastrointestinal bleeding. The primary outcome was a composite of inpatient death, rebleeding, or need for surgery or intensive care unit admission. Endoscopy timing was defined as very early and early. We performed the analysis in two subgroups: (1) high-risk vs. low-risk patients and (2) variceal vs. nonvariceal bleeding.

resultsA total of 102 patients were included, of whom 59.8% underwent urgent endoscopy. Patients who underwent very early endoscopy received endoscopic therapy more frequently (p=0.001), but there was no improvement in other clinical outcomes. Furthermore, patients at low risk and with nonvariceal bleeding who underwent very early endoscopy had a higher risk of the composite outcome.

conclusionVery early endoscopy does not seem to be associated with improved clinical outcomes and may lead to poorer outcomes in specific populations with upper gastrointestinal bleeding. The actual benefit of very early endoscopy remains controversial and should be further clarified.

Indexed as

Endoscopy, digestive systemEndoscopy, gastrointestinalGastrointestinal hemorrhageHemostasis, endoscopicPatient outcome assessment

Identifiers

PMID30300984
PMCPMC6370919

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.