Evidence map›Paper›PMID 30300965›Full record

ArticleActa physiologica (Oxford, England)2019

Epac1

Fitz-Roy E Curry, Torfinn Taxt, Cecilie Brekke Rygh, Tina Pavlin, Ronja Bjønrstad, Stein Ove Døskeland, Rolf K Reed

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Epac1Acta physiologica (Oxford, England) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Fitz-Roy E CurryDepartment of Physiology and Membrane Biology, University of California Davis, Davis, California.
Torfinn TaxtDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Cecilie Brekke RyghDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Tina PavlinDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Ronja BjønrstadDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Stein Ove DøskelandDepartment of Biomedicine, University of Bergen, Bergen, Norway.ORCID 0000-0002-4009-4756
Rolf K ReedDepartment of Biomedicine, University of Bergen, Bergen, Norway.ORCID 0000-0002-2633-6595
University of Bergen · NOUniversity of California, Davis · US

Funding

Helse Vest 911666Helse Vest 911685Research Council of Norway 22325
6 · The paper itself

Abstract

aimEpac1

methodsWe measured DCE-MRI signal intensity in masseter muscle of wt and Epac1

resultsEpac1

conclusionThe study suggests that the normal barrier loosening effect of histamine in venular microvessels do not function when the normal barrier tightening effect of Epac1 is already compromised. The study also demonstrated that the numerical analysis of DCE-MRI data with tracers of different molecular weight has significant limitations.

Indexed as

Magnetic Resonance ImagingMolecular WeightAnimalsCapillary PermeabilityContrast MediaGuanine Nucleotide Exchange FactorsHistamineMice, KnockoutMicrovesselsContrast MediaEpac protein, mouseGuanine Nucleotide Exchange FactorsHistaminecapillary permeabilitycompartment modeldeconvolutionDotaremEpac1histamine

Identifiers

PMID30300965
PMCPMC6646910
OpenAlexW2896659138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.