Evidence map›Paper›PMID 30300890›Full record

ArticleNeonatology2019

Can Fetal Umbilical Venous Blood Be a Reliable Source for Admission Complete Blood Count and Culture in NICU Patients?

Rocky Greer, Azif Safarulla, Robin Koeppel, Muhammad Aslam, Fayez M Bany-Mohammed

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neonatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Minimizing blood sampling in preterm infants.The Cochrane database of systematic reviews · 2026
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Minimizing blood sampling in preterm infants.The Cochrane database of systematic reviews · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rocky GreerDivision of Neonatology, Department of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USA.
Azif SafarullaDivision of Neonatology, Department of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USA.
Robin KoeppelNeonatal Intensive Care Unit, University of California Irvine Medical Center, Orange, California, USA.
Muhammad AslamDivision of Neonatology, Department of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USA.
Fayez M Bany-MohammedDivision of Neonatology, Department of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USAfbanymoh@uci.edu.
University of California, Irvine · USUniversity of California, Irvine Medical Center · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Institutional Career Development CoreKL2TR001416 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, DEMETRIOU, MICHAEL · 2015 to 2023
$5.6M
NCATS NIH HHS KL2 TR001416NCATS NIH HHS UL1 TR001414
6 · The paper itself

Abstract

backgroundMinimizing initial neonatal blood draws and their associated pain is important. The placenta has ample fetal blood that is otherwise discarded; obtaining admission laboratory evaluations from fetal umbilical venous blood (FUVB) may provide a suitable alternative.

objectiveWe hypothesized that obtaining an aerobic bacterial blood culture (BCX) and a complete blood count with manual differential (CBC/diff) from FUVB is feasible and yields results comparable to those obtained directly from the neonate. STUDY

designBCX and CBC/diff were attempted on paired samples from FUVB (in the delivery room) and neonatal blood (shortly after NICU admission) of 110 patients. The paired t test, Pearson's correlation coefficient (R), and multivariable linear regression were used for data analysis.

resultsPositive BCXs were found in 9 of 108 FUVB samples compared to 1 of 91 neonatal samples. Three out of 9 FUVB cultures were true pathogens, including 2 Escherichia coli and 1 viridans group streptococcus, all with negative corresponding paired neonatal cultures. There was 1 positive neonatal BCX, E. coli, with a negative paired FUVB culture. Neonatal hemoglobin (Hb), platelets (PLT), and white blood cells (WBC) all significantly (p < 0.0001) correlated with the paired FUVB samples (R = 0.50, 0.49, and 0.84, respectively). Hb, PLT, and WBC values were clinically comparable but statistically higher in neonatal blood (the differences were 2.3 g/dL, 30,000 cells/μL, and 2,800 cells/μL, respectively; p < 0.007 for all comparisons).

conclusionsFUVB is suitable for obtaining CBC/diff. FUVB is an appropriate second source for BCX as it yields additional true pathogens. Our findings may support the presence of "culture-negative sepsis" in some neonates.

Indexed as

Blood Cell CountIntensive Care Units, NeonatalUmbilical CordBlood Specimen CollectionFemaleFetal BloodHemoglobinsHumansInfant, NewbornInfant, PrematureLinear ModelsMaleMultivariate AnalysisProspective StudiesReference ValuesSepsisHemoglobinsBlood countBlood cultureCord bloodNeonatal sepsisUmbilical venous blood

Identifiers

PMID30300890
PMCPMC6621551
OpenAlexW2896881401

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.