Evidence map›Paper›PMID 30300731›Full record

ArticleBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2019

Reduced-Intensity Conditioning with Fludarabine, Melphalan, and Total Body Irradiation for Allogeneic Hematopoietic Cell Transplantation: The Effect of Increasing Melphalan Dose on Underlying Disease and Toxicity.

George L Chen, Theresa Hahn, Gregory E Wilding, Adrienne Groman, Alan Hutson, Yali Zhang, Usman Khan, Hong Liu, Maureen Ross, Barbara Bambach and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Allogeneic Hematopoietic Cell Transplantation for Relapsed/Refractory Hodgkin Lymphoma: A Multicenter Real-World ExperienceTurkish journal of haematology : official journal of Turkish Society of Haematology · 2026
    Article
  2. Review
  3. Article
  4. The incidence of severe oral mucositis in patients undergoing different conditioning regimens in haematopoietic stem cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

George L ChenBMT Program, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York. Electronic address: george.chen@roswellpark.org.
Theresa HahnBMT Program, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Gregory E WildingDepartment of Biostatistics, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York.
Adrienne GromanDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Alan HutsonDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Yali ZhangBMT Program, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Usman KhanBMT Program, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Hong LiuDepartment of Oncology, Buffalo Medical Group, Buffalo, New York.
Maureen RossBMT Program, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Barbara BambachDepartment of Pediatrics, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Meghan HigmanDepartment of Pediatrics, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Vishala NeppalliDepartment of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Sheila SaitCytogenetics Laboratory, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
AnneMarie W BlockCytogenetics Laboratory, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Paul K WallaceFlow Cytometry Laboratory, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Anurag K SinghDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Philip L McCarthyBMT Program, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Roswell Park Comprehensive Cancer Center · USBuffalo Medical Group · USUniversity at Buffalo, State University of New York · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
RPCI-UPCI Ovarian Cancer SPOREP50CA159981 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MOYSICH, KIRSTEN B. · 2013 to 2025
$19.6M
NCI NIH HHS P30 CA016056NCI NIH HHS P50 CA159981
6 · The paper itself

Abstract

Disease relapse and toxicity are the shortcomings of reduced-intensity conditioning (RIC) for allogeneic hematopoietic cell transplantation (alloHCT). We hypothesized that adding total body irradiation (TBI) to and decreasing melphalan (Mel) from a base RIC regimen of fludarabine (Flu) and Mel would increase cytoreduction and improve disease control while decreasing toxicity. We performed a phase II trial of Flu 160 mg/m

Indexed as

AdolescentAdultAgedAntineoplastic Combined Chemotherapy ProtocolsChildFemaleHematopoietic Stem Cell TransplantationHumansMaleMelphalanMiddle AgedTransplantation ConditioningTransplantation, HomologousVidarabineWhole-Body IrradiationYoung AdultfludarabineMelphalanVidarabineFludarabineMelphalanMinimal residual diseaseReduced-intensity conditioningTotal body irradiation

Identifiers

PMID30300731
PMCPMC6451676
OpenAlexW2895136172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.