Evidence map›Paper›PMID 30300581›Full record

ArticleCancer cell2018

Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting.

Antonia Rotolo, Valentina S Caputo, Monika Holubova, Nicoleta Baxan, Olivier Dubois, Mohammed Suhail Chaudhry, Xiaolin Xiao, Katerina Goudevenou, David S Pitcher, Kyriaki Petevi and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 174 citations in OpenAlex.

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  15. Article
  16. Facts and Hopes of Chimeric Antigen Receptor-Redirected NK T Cells.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Review
  17. Review
  18. Article
  19. Targeting orthotopic and metastatic pancreatic cancer with allogeneic stem cell-engineered mesothelin-redirected CAR-NKT cells.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Antonia RotoloCentre for Haematology, Department of Medicine, Imperial College London, London, UK.
Valentina S CaputoCentre for Haematology, Department of Medicine, Imperial College London, London, UK.
Monika HolubovaCentre for Haematology, Department of Medicine, Imperial College London, London, UK; Biomedical Center, Medical Faculty in Pilsen, Charles University, Alej Svobody 76, Pilsen 323 00, Czech Republic.
Nicoleta BaxanBiological Imaging Centre, Department of Medicine, Imperial College London, London, UK.
Olivier DuboisBiological Imaging Centre, Department of Medicine, Imperial College London, London, UK.
Mohammed Suhail ChaudhryCentre for Haematology, Department of Medicine, Imperial College London, London, UK.
Xiaolin XiaoCentre for Haematology, Department of Medicine, Imperial College London, London, UK.
Katerina GoudevenouCentre for Haematology, Department of Medicine, Imperial College London, London, UK.
David S PitcherCentre for Haematology, Department of Medicine, Imperial College London, London, UK.
Kyriaki PeteviCentre for Haematology, Department of Medicine, Imperial College London, London, UK.
Carolina KachramanoglouDepartment of Neuroradiology, Imperial College Healthcare NHS Trust, London, UK.
Sandra IlesCellular Pathology, Hammersmith Hospital, Northwest London Pathology, London, UK.
Kikkeri NareshCentre for Haematology, Department of Medicine, Imperial College London, London, UK.
John MaherKing's College London, School of Cancer and Pharmaceutical Sciences, Guy's Hospital, London, UK.
Anastasios KaradimitrisCentre for Haematology, Department of Medicine, Imperial College London, London, UK. Electronic address: a.karadimitris@imperial.ac.uk.
Imperial College London · GBCharles University · CZGuy's Hospital · GBHammersmith Hospital · GBImperial College Healthcare NHS Trust · GBNIHR Imperial Biomedical Research Centre · GB

Funding

Medical Research Council MC_PC_16046
6 · The paper itself

Abstract

Chimeric antigen receptor anti-CD19 (CAR19)-T cell immunotherapy-induced clinical remissions in CD19

Indexed as

Cell- and Tissue-Based TherapyAnimalsAntigens, CD19Antigens, CD1dHumansImmunotherapyLeukemia, Lymphocytic, Chronic, B-CellLymphomaMiceNatural Killer T-CellsAntigens, CD19Antigens, CD1dCD1D protein, humanB cell malignanciesCAR immunotherapyiNKT

Identifiers

PMID30300581
PMCPMC6179961
OpenAlexW2896659686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.