Evidence map›Paper›PMID 30300576›Full record

ArticleCancer cell2018

Complement C5a-Mediated TAM-ing of Antitumor Immunity Drives Squamous Carcinogenesis.

Dimitrios C Mastellos, Edimara S Reis, John D Lambris

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cancer cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury.Translational research : the journal of laboratory and clinical medicine · 2021
    Article
  4. Targeting the Complement Pathway in Malignant Glioma Microenvironments.Frontiers in cell and developmental biology · 2021
    Review
  5. Complementing the Cancer-Immunity Cycle.Frontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Dimitrios C MastellosDivision of Biodiagnostic Sciences and Technologies, INRASTES, National Center for Scientific Research "Demokritos," Aghia Paraskevi, Athens, Greece.
Edimara S ReisDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA, USA.
John D LambrisDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA, USA. Electronic address: lambris@pennmedicine.upenn.edu.
University of Pennsylvania · USNational Centre of Scientific Research "Demokritos" · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue of Cancer Cell, Medler et al. demonstrate that fibrinolytic enzyme-mediated generation of complement C5a reprograms tumor-infiltrating C5aR1

Indexed as

Carcinoma, Squamous CellComplement C5aCarcinogenesisHumansReceptor, Anaphylatoxin C5aT-LymphocytesComplement C5aReceptor, Anaphylatoxin C5a

Identifiers

PMID30300576
OpenAlexW2897722667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.