ReviewMenopause (New York, N.Y.)2019
The mysteries of menopause and urogynecologic health: clinical and scientific gaps.
Review in Menopause (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 84 citations in OpenAlex.
- Efficacy ofNutrients · 2024Trial
- Does preoperative locally applied estrogen treatment facilitate prolapse-associated symptoms in postmenopausal women with symptomatic pelvic organ prolapse? A randomised controlled double-masked, placebo-controlled, multicentre study.BJOG : an international journal of obstetrics and gynaecology · 2021Trial
- Mid-Term Outcomes of Laparoscopic Versus Vaginal Uterosacral Ligament Suspension for Pelvic Organ Prolapse: A Propensity Score Overlap-Weighted Retrospective Cohort Study.International urogynecology journal · 2026Article
- Managing the silent burden: a grounded theory study on urinary incontinence in older women.BMC geriatrics · 2026Article
- Navigating the challenges of overactive bladder management in women.World journal of urology · 2026Review
- Long-term effectiveness, body image, satisfaction, regret rate and quality of life following a modified total colpocleisis for treating advanced pelvic organ prolapse in elderly women.International urology and nephrology · 2026Article
- Incidence and Risk Factors of Postoperative Urinary Retention After Thyroidectomy: A Retrospective Cohort Study.World journal of surgery · 2026Article
- A Roadmap for Advancing Women's Health in Disorders of the Gut-Brain Interaction.United European gastroenterology journal · 2026Review
- Shift work and hormonal-circadian disruption raise urinary incontinence: a narrative review.Gynecology and pelvic medicine · 2026Review
- Unveiling urethral cellular heterogeneity in menopause through single-nucleus RNA sequencing.Frontiers in physiology · 2026Article
- Health History, Health Condition, Health Behaviours and Health-Seeking Behaviours of Middle-Aged Women Living in a Modern Rural Community: A Survey Research.Nursing open · 2025Observational
- Development of a Vaginal Extracellular Matrix Hydrogel for Combating Genitourinary Syndrome of Menopause.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Symptom Burden, Treatment Goals, and Information Needs of Younger Women with Pelvic Organ Prolapse: A Content Analysis of ePAQ-Pelvic Floor Free-Text Responses.Journal of clinical medicine · 2025Article
- Relation between pelvic organ prolapse and menopausal hormone therapy: nationwide cohort study.Obstetrics & gynecology science · 2025Article
- Innovating Care for Postmenopausal Women Using a Digital Approach for Pelvic Floor Dysfunctions: Prospective Longitudinal Cohort Study.JMIR mHealth and uHealth · 2025Article
- Review
- The Effects of Diet, Dietary Supplements, Drugs and Exercise on Physical, Diagnostic Values of Urine Characteristics.Nutrients · 2024Review
- Bidirectional Relationships between Sarcopenia and Pelvic Floor Disorders.International journal of environmental research and public health · 2024Review
- Novel Antimicrobial Approaches to Combat Bacterial Biofilms Associated with Urinary Tract Infections.Antibiotics (Basel, Switzerland) · 2024Review
- A Bird's-Eye View of the Pathophysiologic Role of the Human Urobiota in Health and Disease: Can We Modulate It?Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesA significant body of knowledge implicates menopausal estrogen levels in the pathogenesis of the common pelvic floor disorders (PFDs). These health conditions substantially decrease quality of life, increase depression, social isolation, caregiver burden, and economic costs to the individuals and society.
methodsThis review summarizes the epidemiology of the individual PFDs with particular attention to the understanding of the relationship between each PFD and menopausal estrogen levels, and the gaps in science and clinical care that affect menopausal women. In addition, we review the epidemiology of recurrent urinary tract infection (rUTI)-a condition experienced frequently and disproportionately by menopausal women and hypothesized to be potentiated by menopausal estrogen levels.
resultsThe abundance of estrogen receptors in the urogenital tract explains why the natural reduction of endogenous estrogen, the hallmark of menopause, can cause or potentiate PFDs and rUTIs. A substantial body of epidemiological literature suggests an association between menopause, and PFDs and rUTIs; however, the ability to separate this association from age and other comorbid conditions makes it difficult to draw definitive conclusions on the role of menopause alone in the development and/or progression of PFDs. Similarly, the causative link between the decline in endogenous estrogen levels and the pathogenesis of PFDs and rUTIs has not been well-established.
conclusionsInnovative human studies, focused on the independent effects of menopausal estrogen levels, uncoupled from tissue and cellular senescence, are needed.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.