Evidence map›Paper›PMID 30300285›Full record

ArticleTransplantation2019

Temporal Trends Associated With the Rise in Alcoholic Liver Disease-related Liver Transplantation in the United States.

George Cholankeril, Chiranjeevi Gadiparthi, Eric R Yoo, Brittany B Dennis, Andrew A Li, Menghan Hu, Katherine Wong, Donghee Kim, Aijaz Ahmed

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

George CholankerilDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA.
Chiranjeevi GadiparthiDivision of Gastroenterology and Hepatology, Saint Peter's University Hospital, New Brunswick, NJ.
Eric R YooDepartment of Internal Medicine, Santa Clara Valley Medical Center, Santa Clara, CA.
Brittany B DennisDepartment of Medicine, Saint Georges Hospital, University of London, London, United Kingdom.
Andrew A LiDepartment of Medicine, Stanford University School of Medicine, Stanford, CA.
Menghan HuDepartment of Biostatistics, Brown University, Providence, RI.
Katherine WongDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA.
Donghee KimDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA.
Aijaz AhmedDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA.
Stanford University · USBrown University · US

Funding

TRAINING GRANT IN ACADEMIC GASTROENTEROLOGYT32DK007056 · NIDDK · STANFORD UNIVERSITY · PI Natalie J. Torok · 1986 to 2026
$6.5M
NIDDK NIH HHS T32 DK007056
6 · The paper itself

Abstract

backgroundIn the United States, alcoholic liver disease (ALD) has recently become the leading indication for liver transplantation.

methodsUsing the United Network for Organ Sharing registry, we examined temporal trends in adult liver transplant waitlist (WL) registrants and recipients with chronic liver disease (CLD) due to ALD from 2007 to 2016.

resultsFrom 2007 to 2016, ALD accounted for 20.4% (18 399) of all CLD WL additions. The age-standardized ALD WL addition rate was 0.459 per 100 000 US population in 2007; nearly doubled to 0.872 per 100 000 US population in 2016 and increased with an average annual percent change of 47.56% (95% confidence interval, 30.33% to 64.72%).The ALD WL addition rate increased over twofold among young (18-39 years) and middle-aged (40-59 years) adults during the study period. Young adult ALD WL additions presented with a higher severity of liver disease including Model for End-Stage Liver Disease score compared to middle aged and older adults (≥60 years). The number of annual ALD WL deaths readily rose from 2014 to 2016, despite an overall annual decline in all CLD WL deaths. Severe hepatic encephalopathy, low body mass index (<18.5) and diabetes mellitus were significant predictors for 1-year WL mortality.

conclusionsAlcoholic liver disease-related WL registrations and liver transplantation have increased over the past decade with a disproportionate increase in young and middle-aged adults. These subpopulations within the ALD cohort need to be evaluated in future studies to improve our understanding of factors associated with these alarming trends.

Indexed as

AdolescentAdultAge DistributionFemaleHumansLiver Diseases, AlcoholicLiver TransplantationMaleMiddle AgedPrevalenceRegistriesRetrospective StudiesRisk FactorsSex DistributionTime FactorsTreatment Outcome

Identifiers

PMID30300285
PMCPMC6709987
OpenAlexW2896380141

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.