Evidence map›Paper›PMID 30299508›Full record

SynthesisJournal of the National Cancer Institute2018

Targeting Exercise Interventions to Patients With Cancer in Need: An Individual Patient Data Meta-Analysis.

Laurien M Buffart, Maike G Sweegers, Anne M May, Mai J Chinapaw, Jonna K van Vulpen, Rob U Newton, Daniel A Galvão, Neil K Aaronson, Martijn M Stuiver, Paul B Jacobsen and 39 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the National Cancer Institute, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
  2. Do Patients with Prostate Cancer Benefit from Exercise Interventions? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
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  7. Guideline
  8. Exercise on quality of life and cancer-related fatigue for lymphoma survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  9. Systematic review and meta-analysis of maintenance of physical activity behaviour change in cancer survivors.The international journal of behavioral nutrition and physical activity · 2019
    Pooled it
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  14. Association of self-directed walking with toxicity moderation during chemotherapy for the treatment of early breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

49 authors.

Laurien M BuffartDepartment of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.
Maike G SweegersDepartment of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.
Anne M MayJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.
Mai J ChinapawDepartment of Public and Occupational Health, Amsterdam Public Health research institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Jonna K van VulpenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.
Rob U NewtonExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
Daniel A GalvãoExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
Neil K Aaronson
Martijn M StuiverDivision of Psychosocial Research and Epidemiology (NKA) and Center for Quality of life, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Paul B JacobsenDivision of Cancer Control and Population Science, National Cancer Institute, Bethesda, MD.
Irma M Verdonck-de LeeuwDepartment of Clinical Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
Karen SteindorfDivision of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Melinda L IrwinYale School of Public Health, New Haven, CT.
Sandi HayesSchool of Public Health and Social Work, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Kathleen A GriffithThe George Washington University School of Nursing, Washington, DC.
Alejandro LuciaEuropean University and Research Institute, Madrid, Spain.
Fernando Herrero-RomanFundación GIAFyS Cancer, Miranda de Ebro, Spain.
Ilse MestersDepartment of Epidemiology, Maastricht University, Maastricht, the Netherlands.
Ellen van WeertUniversity Medical Centre Groningen, University of Groningen, Center for Rehabilitation, Groningen, the Netherlands.
Hans KnoopDepartment of Medical Psychology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Martine M GoedendorpDepartment of Health Psychology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Nanette MutriePhysical Activity for Health Research Center, University of Edinburgh, Edinburgh, UK.
Amanda J DaleySchool of Sports, Exercise and Health Sciences, University of Loughborough, Loughborough, UK.
Alex McConnachieRobertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Martin BohusInstitute of Psychiatric and Psychosomatic Psychotherapy, Central Institute of Mental Health, Mannheim, Heidelberg University, Heidelberg, Germany.
Lene ThorsenNational Advisory Unit on Late Effects after Cancer Treatment, Department of Oncology (LT) and Department of Clinical Service (LT), Oslo University Hospital, Oslo, Norway.
Karl-Heinz SchulzAthleticum - Competence Center for Sports- and Exercise Medicine and Institute for Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Camille E ShortFreemasons Foundation Centre of Men's Health, School of Medicine, University of Adelaide, Adelaide, SA, Australia.
Erica L James
Ronald C PlotnikoffSchool of Medicine & Public Health (ELJ) and Priority Research Centre for Physical Activity and Nutrition (RCP), The University of Newcastle, Callaghan, NSW, Australia.
Gill ArbaneLane Fox Respiratory Research Unit, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Martina E SchmidtDivision of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Karin PotthoffDepartment of Medical Oncology (KP, JmW) and Department of Radiation Oncology (KP), National Center for Tumor Diseases (NCT) and Heidelberg University Hospital, Heidelberg, Germany.
Marc van BeurdenNetherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Hester S OldenburgNetherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Gabe S SonkeNetherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Wim H van HartenDivision of Psychosocial Research and Epidemiology (NKA) and Center for Quality of life, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Rachel GarrodDepartment of Respiratory Medicine, Kings College London, London, UK.
Kathryn H SchmitzDepartment of Public Health Science, College of Medicine and Cancer Institute, Pennsylvania State University, Hershey, PA.
Kerri M Winters-StoneKnight Cancer Institute and School of Nursing, Oregon Health & Science University, Portland, OR.
Miranda J VelthuisDepartment of Medical Oncology (KP, JmW) and Department of Radiation Oncology (KP), National Center for Tumor Diseases (NCT) and Heidelberg University Hospital, Heidelberg, Germany.
Dennis R TaaffeExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
Willem van MechelenDepartment of Public and Occupational Health, Amsterdam Public Health research institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Marie José KerstenDepartment of Hematology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Frans NolletDepartment of Rehabilitation, Amsterdam UMC, University of Amsterdam, Amsterdam Movement Sciences Research Institute, Amsterdam, the Netherlands.
Jennifer WenzelJohns Hopkins School of Nursing, Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD.
Joachim Wiskemann
Johannes BrugAmsterdam School of Communication Research (ASCoR), University of Amsterdam, Amsterdam, the Netherlands.
Kerry S CourneyaFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Exercise effects in cancer patients often appear modest, possibly because interventions rarely target patients most in need. This study investigated the moderator effects of baseline values on the exercise outcomes of fatigue, aerobic fitness, muscle strength, quality of life (QoL), and self-reported physical function (PF) in cancer patients during and post-treatment. Methods: Individual patient data from 34 randomized exercise trials (n = 4519) were pooled. Linear mixed-effect models were used to study moderator effects of baseline values on exercise intervention outcomes and to determine whether these moderator effects differed by intervention timing (during vs post-treatment). All statistical tests were two-sided. Results: Moderator effects of baseline fatigue and PF were consistent across intervention timing, with greater effects in patients with worse fatigue (Pinteraction = .05) and worse PF (Pinteraction = .003). Moderator effects of baseline aerobic fitness, muscle strength, and QoL differed by intervention timing. During treatment, effects on aerobic fitness were greater for patients with better baseline aerobic fitness (Pinteraction = .002). Post-treatment, effects on upper (Pinteraction < .001) and lower (Pinteraction = .01) body muscle strength and QoL (Pinteraction < .001) were greater in patients with worse baseline values. Conclusion: Although exercise should be encouraged for most cancer patients during and post-treatments, targeting specific subgroups may be especially beneficial and cost effective. For fatigue and PF, interventions during and post-treatment should target patients with high fatigue and low PF. During treatment, patients experience benefit for muscle strength and QoL regardless of baseline values; however, only patients with low baseline values benefit post-treatment. For aerobic fitness, patients with low baseline values do not appear to benefit from exercise during treatment.

Indexed as

ExerciseExercise TherapyHumansNeoplasmsPatient Reported Outcome MeasuresQuality of LifeRandomized Controlled Trials as Topic

Identifiers

PMID30299508
PMCPMC6454466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.