ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2018
Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- TOMM40 genetic variants associated with healthy aging and longevity: a systematic review.BMC geriatrics · 2022Pooled it
- A meta-analysis of genome-wide association studies identifies multiple longevity genes.Nature communications · 2019Pooled it
- TOMM40 may mediate GFAP, neurofilament light Protein, pTau181, and brain morphometry in aging.Aging brain · 2025Article
- All-Cause Mortality and Cause-Specific Death in U.S. Long-Lived Siblings: Data From the Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- The Role of TOMM40 in Cardiovascular Mortality and Conduction Disorders: An Observational Study.Journal of clinical medicine · 2024Article
- How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis.Frontiers in aging · 2024Article
- Article
- The Construction of a Multidomain Risk Model of Alzheimer's Disease and Related Dementias.Journal of Alzheimer's disease : JAD · 2023Article
- APOE ɛ4 allele and TOMM40-APOC1 variants jointly contribute to survival to older ages.Aging cell · 2022Article
- Article
- Rehabilitation of Older Adults with Sarcopenia: From Cell to Functioning.Progress in rehabilitation medicine · 2022Review
- Gene-Environment Interactions and Stochastic Variations in the Gero-Exposome.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.Mechanisms of ageing and development · 2021Article
- Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals.Aging cell · 2021Article
- Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity.Mechanisms of ageing and development · 2021Review
- FamEvent: An R Package for Generating and Modeling Time-to-Event Data in Family Designs.Journal of statistical software · 2021Article
- Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry.JAMA network open · 2020Article
- Genetics of physiological dysregulation: findings from the long life family study using joint models.Aging · 2020Article
- Context-dependent genetic architecture of Drosophila life span.PLoS biology · 2020Article
- The genetics of human ageing.Nature reviews. Genetics · 2020Review
Corrections and comments
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Authors and funding
19 authors at 8 institutions in 2 countries.
Funding
Abstract
The special design of the Long Life Family Study provides a unique opportunity to investigate the genetics of human longevity by analyzing data on exceptional lifespans in families. In this article, we performed two series of genome wide association studies of human longevity which differed with respect to whether missing lifespan data were predicted or not predicted. We showed that the use of predicted lifespan is most beneficial when the follow-up period is relatively short. In addition to detection of strong associations of SNPs in APOE, TOMM40, NECTIN2, and APOC1 genes with longevity, we also detected a strong new association with longevity of rs1927465, located between the CYP26A1 and MYOF genes on chromosome 10. The association was confirmed using data from the Health and Retirement Study. We discuss the biological relevance of the detected SNPs to human longevity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.