ArticleeLife2018
The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
84 citing papers in PubMed, 134 citations in OpenAlex.
- Identification of unannotated microproteins involved in endothelial cell homeostasis, dysfunction, and vascular disease.Cardiovascular research · 2026Article
- Microproteins in Human Physiology and Pathology.Biochemistry · 2026Review
- The Landscape of SERCA2 in Cardiovascular Diseases: Expression Regulation, Therapeutic Applications, and Emerging Roles.Biomolecules · 2026Review
- Sarco/Endoplasmic Reticulum CaJournal of the American Heart Association · 2026Article
- Microprotein, macro-effect: DWORF as a therapeutic strategy in heart failure.Frontiers in cell and developmental biology · 2026Review
- Role of Perturbations of Epigenetic Processes in Cardiac Hypertrophy and Fibrotic Scarring.Current cardiology reviews · 2026Review
- The SERCA-PLN-DWORF axis in cardiometabolic disease: mechanisms and therapeutic perspectives.Cardiovascular diabetology · 2025Review
- MCARE enhances SERCA1 activity in fast-twitch muscle to maintain calcium handling and muscle integrity.Nature communications · 2025Article
- Stress-Induced calcium mishandling in cardiac (Patho)physiology.Cellular and molecular life sciences : CMLS · 2025Review
- RNA Therapeutics in Heart Failure.Journal of cardiovascular translational research · 2025Review
- Micropeptides in the oncological dark matter: decoding their roles in tumor progression and therapy resistance.Journal of translational medicine · 2025Review
- RRAD-reduction reveals efficacy of targeting L-type calcium channel regulation for treatment of heart failure.Cardiovascular research · 2025Article
- Chasing the Ghost Proteome in the Dark Matter.Molecular & cellular proteomics : MCP · 2025Review
- Allosteric Modulation of SERCA Pumps in Health and Disease: Structural Dynamics, Posttranslational Modifications, and Therapeutic Potential.Journal of molecular biology · 2025Review
- DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function.Circulation research · 2025Article
- Abnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout mice.Science advances · 2025Article
- A biodegradable, microstructured, electroconductive and nano-integrated drug eluting patch (MENDEP) for myocardial tissue engineering.Bioactive materials · 2025Article
- S-Nitrosylation in Cardiovascular Disorders: The State of the Art.Biomolecules · 2025Review
- Calcium-dependent levels of phospholamban pentamer in native heart membranes reflect interactions of monomers with calcium-free SERCA2a.Archives of biochemistry and biophysics · 2025Article
- Microproteins in Metabolism.Cells · 2025Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Catherine A MakarewichDepartment of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States.ORCID https://orcid.org/0000-0001-6907-4401
Amir Z MunirDepartment of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Gabriele G SchiattarellaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Svetlana BezprozvannayaDepartment of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Olga N RaguimovaDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, United States.
Ellen E ChoDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, United States.
Alexander H VidalDepartment of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Seth L RobiaDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, United States.
Rhonda Bassel-DubyDepartment of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Eric N OlsonDepartment of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States.ORCID https://orcid.org/0000-0003-1151-8262
The University of Texas Southwestern Medical Center · USLoyola University Chicago · US
Funding
Structural Determinants of Calcium Pump RegulationR01HL092321 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia · 2008 to 2026
$8.9MTraining CoreP50HD087351 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI OLSON, ERIC N · 2020 to 2024
$8.0MTraining CoreU54HD087351 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI OLSON, ERIC N · 2015 to 2019
$7.8MDeciphering the role of a novel micropeptide in cardiac function and dysfunctionR01HL130253 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA, OLSON, ERIC N · 2016 to 2023
$4.4MNew mechanisms of SERCA regulation: Dimerization and MicropeptidesR01HL143816 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia, Gianluigi Veglia · 2019 to 2026
$3.6MMolecular Dissection of Myoblast Fusion In Muscle Development and RegenerationR01AR067294 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA, OLSON, ERIC N · 2015 to 2019
$1.8MChemically assisted remodeling of infarcted heart tissue by targeting Wnt lipidationR01HL138426 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA · 2017 to 2020
$1.7MDissecting the role of novel calcium regulatory proteins in the cardiovascular systemR00HL141630 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI MAKAREWICH, CATHERINE A · 2020 to 2022
$747kRodent Ultrasound Imaging SystemS10RR023729 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2009 to 2009
$290kDissecting the role of novel calcium regulatory proteins in the cardiovascular systemK99HL141630 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI MAKAREWICH, CATHERINE A · 2018 to 2019
$177kElucidation of the Role of a Novel Cardiac Micropeptide in the Control of Heart Function and DysfunctionF32HL129674 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI MAKAREWICH, CATHERINE A · 2015 to 2018
$124kNCRR NIH HHS S10 RR023729NHLBI NIH HHS F32 HL129674NHLBI NIH HHS K99 HL141630NHLBI NIH HHS R00 HL141630NHLBI NIH HHS R01 HL092321NHLBI NIH HHS R01 HL130253NHLBI NIH HHS R01 HL138426NHLBI NIH HHS R01 HL143816NIAMS NIH HHS R01 AR067294NICHD NIH HHS P50 HD087351NICHD NIH HHS U54 HD087351NIH HHS F32 (HL-129674)NIH HHS K99 (HL-141630)NIH HHS R01 (AR-067294)NIH HHS R01 (HD-087351)NIH HHS R01 (HL-092321)NIH HHS R01 (HL-130253)NIH HHS R01 (HL-138426)
Abstract
Calcium (Ca
Indexed as
AnimalsCalcium-Binding ProteinsCardiomyopathy, DilatedDisease Models, AnimalGene Knockout TechniquesHeart FailureLIM Domain ProteinsMice, KnockoutMuscle ProteinsMyocardial ContractionPeptidesPhospholambanSarcoplasmic Reticulum Calcium-Transporting ATPasesCalcium-Binding Proteinscysteine and glycine-rich protein 3DWORF peptide, mouseLIM Domain ProteinsMuscle ProteinsPeptidesPhospholambanSarcoplasmic Reticulum Calcium-Transporting ATPasescalciumcardiaccardiomyopathycell biologycontractilityheart failuremouseSERCA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.