ArticleEvolution; international journal of organic evolution2018
A genotypic trade-off between constitutive resistance to viral infection and host growth rate.
Article in Evolution; international journal of organic evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Genomic Structure Predicts Granulovirus Resistance Without a Detectable Life-History Trade-Off in Plodia interpunctella.Molecular ecology · 2026Article
- Article
- Resource reallocation under persistent immune activation drives trade-offs between life history and immunity in pirk-deficient Musca domestica.BMC biology · 2025Article
- Disease resistance is more costly at younger ages: An explanation for the maintenance of juvenile susceptibility in a wild plant.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Warming During Different Life Stages has Distinct Impacts on Host Resistance Ecology and Evolution.Ecology letters · 2025Article
- Inferring the energy cost of resistance to parasitic infection and its link to a trade-off.BMC ecology and evolution · 2025Article
- Baculovirus Genetic Diversity and Population Structure.Viruses · 2025Review
- Trade-offs between defense and competitive traits in a planktonic predator-prey system.Ecology · 2024Article
- Genetic variation in parasite avoidance, yet no evidence for constitutive fitness costs.Evolution; international journal of organic evolution · 2024Article
- Coevolution of Age-Structured Tolerance and Virulence.Bulletin of mathematical biology · 2024Article
- Specific resistance prevents the evolution of general resistance and facilitates disease emergence.Journal of evolutionary biology · 2023Article
- The Evolution of the Age of Onset of Resistance to Infectious Disease.Bulletin of mathematical biology · 2023Article
- Meta-Analysis of the Effects of Insect Pathogens: Implications for Plant Reproduction.Pathogens (Basel, Switzerland) · 2023Review
- The evolution of age-specific resistance to infectious disease.Proceedings. Biological sciences · 2023Article
- Article
- Reproductive consequences of transient pathogen exposure across host genotypes and generations.Ecology and evolution · 2022Article
- Coevolutionary theory of hosts and parasites.Journal of evolutionary biology · 2022Review
- EfficientFrontiers in genome editing · 2022Article
- Honey Bees (Apis mellifera Hymenoptera: Apidae) Preferentially Avoid Sugar Solutions Supplemented with Field-Relevant Concentrations of Hydrogen Peroxide Despite High Tolerance Limits.Journal of insect science (Online) · 2022Article
- The effects of host plant species and larval density on immune function in the polyphagous mothEcology and evolution · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Genotypic trade-offs are fundamental to the understanding of the evolution of life-history traits. In particular, the evolution of optimal host defense and the maintenance of variation in defense against infectious disease is thought to be underpinned by such evolutionary trade-offs. However, empirical demonstrations of these trade-offs that satisfy the strict assumptions made by theoretical models are rare. Additionally, none of these trade-offs have yet been shown to be robustly replicable using a variety of different experimental approaches to rule out confounding issues with particular experimental designs. Here, we use inbred isolines as a novel experimental approach to test whether a trade-off between viral resistance and growth rate in Plodia interpunctella, previously demonstrated by multiple selection experiments, is robust and meets the strict criteria required to underpin theoretical work in this field. Critically, we demonstrate that this trade-off is both genetic and constitutive. This finding helps support the large body of theory that relies on these assumptions, and makes this trade-off for resistance unique in being replicated through multiple experimental approaches and definitively shown to be genetic and constitutive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.