Evidence map›Paper›PMID 30298790›Full record

ArticleVirulence2018

BabA-mediated adherence of pediatric ulcerogenic H. pylori strains to gastric mucins at neutral and acidic pH.

Macarena P Quintana-Hayashi, Raquel Rocha, Médea Padra, Anders Thorell, Chunsheng Jin, Niclas G Karlsson, Mónica Roxo-Rosa, Mónica Oleastro, Sara K Lindén

Open access · goldAbstract read
In one paragraph

Article in Virulence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Novel anti-virulence strategy againstFrontiers in microbiology · 2026
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  3. Review
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  6. Virulence · 2021
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  7. Review
  8. Review
  9. Toxins · 2019
    Review
  10. Review of current diagnostic methods and advances inWorld journal of gastroenterology · 2019
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Macarena P Quintana-Hayashia Department of Biomedical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.
Raquel Rochab Department of Infectious Diseases , National Institute of Health Dr. Ricardo Jorge , Lisbon , Portugal.
Médea Padraa Department of Biomedical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.
Anders Thorellc Department for Clinical Science and Department of Surgery, Ersta Hospital , Karolinska Institutet , Stockholm , Sweden.
Chunsheng Jina Department of Biomedical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.
Niclas G Karlssona Department of Biomedical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.
Mónica Roxo-Rosab Department of Infectious Diseases , National Institute of Health Dr. Ricardo Jorge , Lisbon , Portugal.ORCID 0000-0001-6360-2576
Mónica Oleastrod Centro de Estudo de Doenças Crónicas, Nova Medical School/Faculdade de Ciências Médicas , Universidade Nova de Lisboa , Lisbon , Portugal.ORCID 0000-0001-6360-2576
Sara K Lindéna Department of Biomedical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.
University of Gothenburg · SENational Institute of Health Dr. Ricardo Jorge · PTKarolinska Institutet · SEUniversidade Nova de Lisboa · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helicobacter pylori infection can result in non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), adenocarcinoma, and gastric lymphoma. H. pylori reside within the gastric mucus layer, mainly composed of mucins carrying an array of glycan structures that can serve as bacterial adhesion epitopes. The aim of the present study was to characterize the binding ability, adhesion modes, and growth of H. pylori strains from pediatric patients with NUD and PUD to gastric mucins. Our results showed an increased adhesion capacity of pediatric PUD H. pylori strains to human and rhesus monkey gastric mucins compared to the NUD strains both at neutral and acidic pH, regardless if the mucins were positive for Lewis b (Le

Indexed as

Bacterial AdhesionAdhesins, BacterialAdolescentAnimalsChildChild, PreschoolFemaleGastric MucinsGene Knockout TechniquesGenotypeGlycosylationHelicobacter pyloriHumansHydrogen-Ion ConcentrationInfantMacaca mulattaAdhesins, BacterialBabA protein, Helicobacter pyloriGastric MucinsadhesinbabAbindingchildrenglycosylationHelicobacter pyloriMucinpeptic ulcerpHvirulence

Identifiers

PMID30298790
PMCPMC7000205
OpenAlexW2904568842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.