ArticleCNS neuroscience & therapeutics2019
Metabolic covariance networks combining graph theory measuring aberrant topological patterns in mesial temporal lobe epilepsy.
Article in CNS neuroscience & therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives.Frontiers in neurology · 2022Pooled it
- The Role of Neuroinflammation and Network Anomalies in Drug-Resistant Epilepsy.Neuroscience bulletin · 2025Review
- FDG-PET-based brain network analysis: a brief review of metabolic connectivity.EJNMMI reports · 2025Review
- [European journal of nuclear medicine and molecular imaging · 2025Article
- Metabolic connectivity as a predictor of surgical outcome in mesial temporal lobe epilepsy.Epilepsia open · 2024Article
- Individual metabolic brain network abnormalities associated with drug-resistant mTLE vary in surgical outcomes.Frontiers in neurology · 2024Article
- Altered Metabolic Networks in Mesial Temporal Lobe Epilepsy with Focal to Bilateral Seizures.Brain sciences · 2023Article
- Structural connectome alterations in anxious dogs: a DTI-based study.Scientific reports · 2023Article
- In vivo characterization of magnetic resonance imaging-based T1w/T2w ratios reveals myelin-related changes in temporal lobe epilepsy.Human brain mapping · 2023Article
- Abnormal metabolic connectivity in default mode network of right temporal lobe epilepsy.Frontiers in neuroscience · 2023Article
- Altered metabolic-functional coupling in the epileptogenic network could predict surgical outcomes of mesial temporal lobe epilepsy.Frontiers in neuroscience · 2023Article
- Brain metabolic characteristics distinguishing typical and atypical benign epilepsy with centro-temporal spikes.European radiology · 2021Article
- Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy.Nature reviews. Neurology · 2021Review
- Article
- Individual Brain Metabolic Connectome Indicator Based on Jensen-Shannon Divergence Similarity Estimation Predicts Seizure Outcomes of Temporal Lobe Epilepsy.Frontiers in cell and developmental biology · 2021Article
- Alterations in the metabolic networks of temporal lobe epilepsy patients: A graph theoretical analysis using FDG-PET.NeuroImage. Clinical · 2020Article
- Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus.CNS neuroscience & therapeutics · 2019Article
- Metabolic covariance networks combining graph theory measuring aberrant topological patterns in mesial temporal lobe epilepsy.CNS neuroscience & therapeutics · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to study the networks' mechanism of metabolic covariance networks in mesial temporal lobe epilepsy (mTLE), through examining the brain value of fluorine-18-fluorodeoxyglucose positron emission tomography (
methods
resultsWMPA showed a typical ipsilateral hypometabolism and contralateral hypermetabolism pattern to epileptic zones in mTLE. h-MCN revealed decreased hippocampus-based synchronization in contralateral regions. w-MCN exhibited a disrupted metabolic network with globally increased small-world properties and regionally decreased nodal metrics in the ipsilateral hemisphere. Hippocampus (h)-EBCA and whole brain EBCA (w-EBCA) both detected a reduced-connectivity dominated metabolic covariant network. Moreover, the reduced interhemisphere connectivity seemingly played a major role in the aberrant epileptic topological pattern.
conclusionFrom a metabolic point of view, we demonstrated the damaging effects with reduced contralateral intranetwork metrics properties and the compensatory effects in contralateral intranetworks with increased network properties. However, the import role of significant reduced interhemisphere connection has rarely been reported in other mTLE studies. Taken together,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.