ArticleStatistics in medicine2019
Power and sample size requirements for GEE analyses of cluster randomized crossover trials.
Article in Statistics in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- Trial
- Artificial Intelligence-Based Video Feedback to Improve Novice Performance on Robotic Suturing Skills: A Pilot Study.Journal of endourology · 2024Trial
- The batched stepped wedge design: A design robust to delays in cluster recruitment.Statistics in medicine · 2022Trial
- Effectiveness of a monthly schedule of follow-up for the treatment of uncomplicated severe acute malnutrition in Sokoto, Nigeria: A cluster randomized crossover trial.PLoS medicine · 2022Trial
- What is estimated in cluster randomized crossover trials with informative sizes? A survey of estimands and common estimators.Statistical methods in medical research · 2026Article
- Analysis of Stepped-Wedge Cluster Randomized Trials: A Tutorial Using Marginal Models.Statistics in medicine · 2026Article
- Network generalized estimating equations for complexly correlated data with applications to cluster randomized trials.Biostatistics (Oxford, England) · 2025Article
- [Impact of incorrect designation of working correlation structure matrix on sample size estimation in 2×2 cross design: a simulation study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Design of a cluster-randomized, hybrid type 1 effectiveness-implementation trial of a care navigation intervention to increase substance use disorder treatment engagement: study protocol.Addiction science & clinical practice · 2025Article
- Selecting the optimal longitudinal cluster randomized design with a continuous outcome: Parallel-arm, crossover, or stepped-wedge.Statistical methods in medical research · 2025Article
- Evaluating the Effect of a Molecular Point-of-Care Test on Acute Respiratory Infections in General Practice: Protocol for a Cluster Randomized Trial.JMIR research protocols · 2025Article
- Family Interviews Improve Health Service Recommendations in Mortality Review Process: A Mixed-Methods Assessment.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- Reporting of cluster randomised crossover trials: extension of the CONSORT 2010 statement with explanation and elaboration.BMJ (Clinical research ed.) · 2025Article
- Association between a large change between the minimum and maximum monthly values of solar insolation and a history of suicide attempts in bipolar I disorder.International journal of bipolar disorders · 2024Article
- Optimal design of cluster randomized crossover trials with a continuous outcome: Optimal number of time periods and treatment switches under a fixed number of clusters or fixed budget.Behavior research methods · 2024Article
- Optimal designs using generalized estimating equations in cluster randomized crossover and stepped wedge trials.Statistical methods in medical research · 2024Article
- Sample size and power calculation for testing treatment effect heterogeneity in cluster randomized crossover designs.Statistical methods in medical research · 2024Article
- Using Power Analysis to Choose the Unit of Randomization, Outcome, and Approach for Subgroup Analysis for a Multilevel Randomized Controlled Clinical Trial to Reduce Disparities in Cardiovascular Health.Prevention science : the official journal of the Society for Prevention Research · 2024Article
- Designing individually randomized group treatment trials with repeated outcome measurements using generalized estimating equations.Statistics in medicine · 2024Article
- Generalizing the information content for stepped wedge designs: A marginal modeling approach.Scandinavian journal of statistics, theory and applications · 2023Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
The cluster randomized crossover design has been proposed to improve efficiency over the traditional parallel cluster randomized design, which often involves a limited number of clusters. In recent years, the cluster randomized crossover design has been increasingly used to evaluate the effectiveness of health care policy or programs, and the interest often lies in quantifying the population-averaged intervention effect. In this paper, we consider the two-treatment two-period crossover design, and develop sample size procedures for continuous and binary outcomes corresponding to a population-averaged model estimated by generalized estimating equations, accounting for both within-period and interperiod correlations. In particular, we show that the required sample size depends on the correlation parameters through an eigenvalue of the within-cluster correlation matrix for continuous outcomes and through two distinct eigenvalues of the correlation matrix for binary outcomes. We demonstrate that the empirical power corresponds well with the predicted power by the proposed formulae for as few as eight clusters, when outcomes are analyzed using the matrix-adjusted estimating equations for the correlation parameters concurrently with a suitable bias-corrected sandwich variance estimator.
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