SynthesisInfection2019
Inhaled corticosteroids and risk of upper respiratory tract infection in patients with asthma: a meta-analysis.
Synthesis in Infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Clinical efficacy of inhaled corticosteroids in patients with coronavirus disease 2019: A living review and meta-analysis.PloS one · 2023Pooled it
- Association between ICS use and risk of hyperglycemia in COPD patients: systematic review and meta-analysis.Respiratory research · 2021Pooled it
- Inhaled corticosteroids and risk of influenza in patients with asthma: a meta-analysis of randomized controlled trials.Aging clinical and experimental research · 2021Pooled it
- Effect of comorbid pulmonary disease on the severity of COVID-19: A systematic review and meta-analysis.Respirology (Carlton, Vic.) · 2021Pooled it
- Inhaled corticosteroids and COVID-19: a systematic review and clinical perspective.The European respiratory journal · 2020Pooled it
- Effectiveness and Safety of Budesonide/Formoterol in Asthma: A Systematic Review.Healthcare (Basel, Switzerland) · 2026Review
- Differential association of fluticasone furoate and budesonide with clinically detected COVID-19: a retrospective cohort study.BMJ open respiratory research · 2026Article
- Protective Effect of Allergen Immunotherapy in Patients With Allergic Rhinitis and Asthma Against COVID-19 Infection: Observational, Nationwide, and Multicenter Study.JMIR public health and surveillance · 2024Observational
- Is using inhaled corticosteroid effective against COVID-19 pneumonia severity and mortality?Tuberkuloz ve toraks · 2024Observational
- Sputum pathogen spectrum and clinical outcomes of upper respiratory tract infection in bronchiectasis exacerbation: a prospective cohort study.Emerging microbes & infections · 2023Article
- Relationship between steroid use and superinfections in SARS-CoV-2 patients. A systematic review and meta-analysis.Infection ecology & epidemiology · 2023Review
- Associations between COVID-19 outcomes and asthmatic patients with inhaled corticosteroid.Frontiers in pharmacology · 2023Article
- Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, China.Emerging infectious diseases · 2022Article
- Post-COVID-19 Syndrome: Incidence, Risk Factor, and the Most Common Persisting Symptoms.Cureus · 2022Article
- Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study.Scientific reports · 2022Article
- Do Patients With Chronic Rhinosinusitis Exhibit Elevated Rates of Covid-19 Infection?The Laryngoscope · 2022Article
- Epidemiology, Healthcare Resource Utilization, and Mortality of Asthma and COPD in COVID-19: A Systematic Literature Review and Meta-Analyses.Journal of asthma and allergy · 2022Article
- Inhaled corticosteroids and COVID-19 outcomes in asthma: the Israeli experience.ERJ open research · 2022Article
- Association between Inhaled Corticosteroid Use and SARS-CoV-2 Infection: A Nationwide Population-Based Study in South Korea.Tuberculosis and respiratory diseases · 2022Article
- Asthma and COVID-19: an update.European respiratory review : an official journal of the European Respiratory Society · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecent studies have suggested a possible association between respiratory infection and the use of inhaled corticosteroids (ICS). We aimed to ascertain the risk of upper respiratory tract infection (URTI) with long-term inhaled corticosteroid use among patients with asthma.
methodsThrough a comprehensive literature search of PubMed, Cochrane Library, EMBASE, and Google Scholar from inception to May 2018, we included randomized controlled trials of any ICS vs. a control treatment for asthma, with reporting of URTI as an adverse event. We conducted meta-analyses by the Peto approaches to generate summary estimates comparing ICS with non-ICS treatment on the risk of URTI.
resultsSeventeen trials (15,336 subjects) were included. Compared with non-ICS treatment, ICSs were associated with a significantly increased risk of URTI (Peto OR, 1.24; 95% CI 1.08-1.42; I
conclusionsThis study raises safety concerns about the risk of URTI associated with ICS use in patients with asthma, but it should be further investigated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.