ArticlePediatric radiology2019
Pilot study on renal magnetic resonance diffusion tensor imaging: are quantitative diffusion tensor imaging values useful in the evaluation of children with ureteropelvic junction obstruction?
Article in Pediatric radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 9 citations in OpenAlex.
- Advances in pediatric kidney diffusion tensor imaging: diagnostic and functional applications.Pediatric radiology · 2026Review
- Probing Renal Microstructure and Function with Advanced Diffusion MRI: Concepts, Applications, Challenges, and Future Directions.Journal of magnetic resonance imaging : JMRI · 2024Review
- Assessment of kidney function in chronic kidney disease by combining diffusion tensor imaging and total kidney volume.International urology and nephrology · 2022Article
- Outcome analysis of early surgery and conservative treatment in neonates and infants with severe hydronephrosis.The Journal of international medical research · 2021Article
- Diffusion tensor imaging based multiparametric characterization of renal lesions in infants with urinary tract infections: an explorative study.BMC pediatrics · 2021Article
- DTI of the kidney in children: comparison between normal kidneys and those with ureteropelvic junction (UPJ) obstruction.Magma (New York, N.Y.) · 2020Article
- Relationship of renal apparent diffusion coefficient and functional MR urography in children with pelvicalyceal dilation.Pediatric radiology · 2019Article
- Geometric Distortion Correction of Renal Diffusion Tensor Imaging Using the Reversed Gradient Method.Journal of computer assisted tomographyArticle
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6 authors at 1 institution in 1 country.
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Abstract
backgroundUreteropelvic junction (UPJ) obstruction is a common cause of renal injury in children. Indications for surgery are still controversial. Currently, there is no threshold to differentiate patients with suspected UPJ obstruction requiring surgery from the ones that do not, or to predict renal outcome after surgery. Several studies have demonstrated that diffusion tensor imaging (DTI) results may correlate with microstructural changes in the kidneys.
objectiveTo evaluate the feasibility of using DTI to identify UPJ obstruction kidneys. MATERIALS AND
methodsWe analyzed functional MR urography (fMRU) with renal DTI (b=0 and b=400, 20 directions, 1.5 Tesla, no respiratory triggering) in 26 kidneys of 19 children (mean age: 6.15 years) by comparing 13 kidneys with UPJ obstruction configuration that underwent pyeloplasty following the fMRU, and 13 anatomically normal age- and gender-matched kidneys. DTI tractography was reconstructed using a fractional anisotropy threshold of 0.10 and an angle threshold of 55°. User-defined regions of interest (ROIs) of the renal parenchyma (excluding collecting system) were drawn to quantify DTI parameters: fractional anisotropy, apparent diffusion coefficient (ADC), track length and track volume. The failure rate was evaluated.
resultsAll DTI parameters changed with age; fractional anisotropy decreased (P<0.032). Track volume and track length increased (P<0.05). ADC increased with age in normal kidneys (P<0.001) but not in UPJ obstruction kidneys (P=0.11). After controlling for age, the fractional anisotropy (UPJ obstruction mean: 0.18, normal kidney mean: 0.21; P=0.001) and track length (UPJ obstruction mean: 11.9 mm, normal kidney mean: 15.4 mm; P<0.001) were lower in UPJ obstruction vs. normal kidneys. There was a trend toward a higher ADC in UPJ obstruction kidneys vs. normal kidneys (P=0.062). The failure rate in UPJ obstruction kidneys due to technical limitations of DTI was 13/26 (50%).
conclusionWe demonstrated that fractional anisotropy is lower in UPJ obstruction than in normal kidneys. It is necessary to improve this technique to increase the success rate and to perform more studies to evaluate if a decrease in fractional anisotropy can differentiate UPJ obstruction kidneys from hydronephrotic kidneys without UPJ obstruction.
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