Evidence map›Paper›PMID 30298133›Full record

ReviewFrontiers in nutrition2018

The Role of Polyphenols in Human Health and Food Systems: A Mini-Review.

Hannah Cory, Simone Passarelli, John Szeto, Martha Tamez, Josiemer Mattei

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 522 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
522citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06419231 nacompletednot on this mapstarted 2023, after this paper: background citation

A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of a Butyrate Formulation and a Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2023 to 2025Enrolled143ConditionsGut HealthArmsButyrate Formulation, Butyrate + Polyphenol Formulation, Placebo
NCT07371975 nacompletednot on this mapstarted 2025, after this paper: background citation

A Study to Evaluate the Effects of a Butyrate-Polyphenol Formulation on Gut Health and Associated Symptoms

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2025 to 2026Enrolled124ConditionsGut HealthArmsButyrate + Polyphenol Formulation, Placebo
3 · Its place in the literature

Who cites it

522 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  11. Predicting the Toxicity In Silico of the Aqueous Extract ofPharmaceuticals (Basel, Switzerland) · 2026
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462 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hannah CoryDepartment of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, United States.
Simone PassarelliDepartment of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, United States.
John SzetoMassachusetts General Hospital, Charlestown, MA, United States.
Martha TamezDepartment of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, United States.
Josiemer MatteiDepartment of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, United States.

Funding

Diet quality and cardiometabolic disparities among Latino ethnic subgroupsK01HL120951 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI MATTEI, JOSIEMER · 2014 to 2018
$689k
NHLBI NIH HHS K01 HL120951
6 · The paper itself

Abstract

This narrative mini- review summarizes current knowledge of the role of polyphenols in health outcomes-and non-communicable diseases specifically-and discusses the implications of this evidence for public health, and for future directions for public health practice, policy, and research. The publications cited originate mainly from animal models and feeding experiments, as well as human cohort and case-control studies. Hypothesized protective effects of polyphenols in acute and chronic diseases, including obesity, neurodegenerative diseases, type 2 diabetes, and cardiovascular diseases, are evaluated. Potential harmful effects of some polyphenols are also considered, counterbalanced with the limited evidence of harm in the research literature. Recent international governmental regulations are discussed, as the safety and health claims of only a few specific polyphenolic compounds have been officially sanctioned. The implications of food processing on the bioavailability of polyphenols are also assessed, in addition to the health claims and marketing of polyphenols as a functional food. Finally, this mini-review asserts the need for increased regulation and guidelines for polyphenol consumption and supplementation in order to ensure consumers remain safe and informed about polyphenols.

Indexed as

antioxidantschronic diseasefood systemsfunctional foodspolyphenols

Identifiers

PMID30298133
PMCPMC6160559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.