ArticleNature communications2018
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
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In one paragraph
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 78 citations in OpenAlex.
- DiscERN: an automated genome mining tool for the discovery of evolutionarily related natural products.Nature communications · 2026Article
- Transcription attenuation amplifies collateral vulnerabilities in rifampicin-resistant Mycobacterium tuberculosis.Nature microbiology · 2026Article
- PhoP-regulated VirK acts as an accessory factor to maintain virulence in polymyxin-resistant Klebsiella pneumoniae.Nucleic acids research · 2026Article
- Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas.Nature microbiology · 2026Article
- New Structure Activity Relationship Insight into the Role of the C-3 Extension on Rifamycin Antimycobacterial Activity.ChemMedChem · 2025Article
- Molecular chameleons adaptability in target binding.Structural dynamics (Melville, N.Y.) · 2025Article
- Article
- Structure of a Cyclic Peptide as an Inhibitor ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Cryo-EM structures of a mycobacterial ABC transporter that mediates rifampicin resistance.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Insights into the genomic and functional divergence of NAT gene family to serve microbial secondary metabolism.Scientific reports · 2024Article
- The shikimate pathway: gateway to metabolic diversity.Natural product reports · 2024Review
- Article
- Integration of (S)-2,3-oxidosqualene enables E. coli to become Iron Man E. coli with improved overall tolerance.Biotechnology for biofuels and bioproducts · 2023Article
- Multifunctional Drugs-Loaded Carbomol Hydrogel Promotes Diabetic Wound Healing via Antimicrobial and Immunoregulation.Gels (Basel, Switzerland) · 2023Article
- Nanoscaled Discovery of a Shunt Rifamycin fromACS infectious diseases · 2023Article
- Megalochelin, a Tridecapeptide Siderophore from a Talented Streptomycete.ACS chemical biology · 2023Article
- Next-generation synthetic biology approaches for the accelerated discovery of microbial natural products.Engineering microbiology · 2023Review
- Article
- Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 1 country.
James PeekLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Mirjana LilicLaboratory of Molecular Biophysics, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Daniel MontielLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Aleksandr MilshteynLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Ian WoodworthLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
John B BigginsLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Melinda A TerneiLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Paula Y CalleLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Michael DanzigerLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Thulasi WarrierDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA.
Kohta SaitoDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA.
Nathaniel BraffmanLaboratory of Molecular Biophysics, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Allison FayImmunology Program, Sloan-Kettering Institute, New York, NY, 10065, USA.
Michael S GlickmanImmunology Program, Sloan-Kettering Institute, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0001-7918-5164
Seth A DarstLaboratory of Molecular Biophysics, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Elizabeth A CampbellLaboratory of Molecular Biophysics, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA. elizabeth.campbell@rockefeller.edu.
Sean F BradyLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA. sbrady@rockefeller.edu.ORCID http://orcid.org/0000-0001-5967-8586
Rockefeller University · USCornell University · USKettering University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MOverall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3MA minimally invasive synthetic bio-driven approach for natural products discoveryU01GM110714 · NIGMS · ROCKEFELLER UNIVERSITY · PI BRADY, SEAN F · 2015 to 2019
$11.1MStructure, function, and regulation of the bacterial transcription cycleR35GM118130 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 2016 to 2025
$8.9MT32: Pathogenesis of Infectious Diseases Training ProgramT32AI007613 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROY M. GULICK · 1999 to 2026
$8.8MDiscovery of Antibiotics from Soil Microbiomes Using MetagenomicsR35GM122559 · NIGMS · ROCKEFELLER UNIVERSITY · PI SEAN F BRADY · 2017 to 2026
$4.7MStructure/function analyses of essential mycobacterial transcription regulatorsR01GM114450 · NIGMS · ROCKEFELLER UNIVERSITY · PI CAMPBELL, ELIZABETH A · 2015 to 2023
$3.4MCrystallization Robot for the Structural Biology Resource Center at RockefellerS10RR027037 · NCRR · ROCKEFELLER UNIVERSITY · PI OREN, DEENA ABELLS · 2010 to 2010
$147kBill and Melinda Gates Foundation OPP1117928NCI NIH HHS P30 CA008748NCRR NIH HHS S10 RR027037NIGMS NIH HHS P41 GM103403NIGMS NIH HHS R01 GM114450NIGMS NIH HHS R35 GM118130NIGMS NIH HHS R35 GM122559NIGMS NIH HHS U01 GM110714U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1R35 GM122559U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5U01 GM110714
Abstract
Rifamycin antibiotics (Rifs) target bacterial RNA polymerases (RNAPs) and are widely used to treat infections including tuberculosis. The utility of these compounds is threatened by the increasing incidence of resistance (Rif
Indexed as
AminobenzoatesAntibiotics, AntitubercularBacteriaBacterial ProteinsDNA-Directed RNA PolymerasesDrug Resistance, BacterialHumansHydroxybenzoatesMetagenomicsMolecular StructureMutationMycobacterium tuberculosisRifampinRifamycinsSoil MicrobiologyTuberculosis3-amino-5-hydroxybenzoic acidAminobenzoatesAntibiotics, AntitubercularBacterial ProteinsDNA-Directed RNA PolymerasesHydroxybenzoateskanglemycin ARifampinRifamycins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.