ArticleNature microbiology2018
Leveraging single-cell genomics to expand the fungal tree of life.
Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Distinct Features Based on Partitioning of the Endophytic Fungi of Cereals and Other Grasses.Microbiology spectrum · 2023Pooled it
- Eukaryotic metagenome-assembled genomes recovered from deep metagenomic sequencing of the seagrass,Microbial genomics · 2026Article
- Single-Thallus Genomics of Ejectosporus trisporus, an Unculturable Stonefly Gut Fungal Symbiont.Environmental microbiology · 2026Article
- Exploring the diversity and community structure of the Testudines fecal mycobiome.bioRxiv : the preprint server for biology · 2026Article
- Environmental Adaptation Strategies of Deep-Sea Fungi.Journal of fungi (Basel, Switzerland) · 2026Review
- The molecular revolution in fungal diagnostics: bridging gaps across clinical, agricultural, and environmental mycology.Mycology · 2026Review
- From fragmentation to resolution: high-fidelity genome assembly of zancudomyces culisetae through comparative insights from PacBio, Nanopore, and Illumina sequencing.G3 (Bethesda, Md.) · 2025Article
- A genomic perspective on fungal diversity and evolution.Nature reviews. Microbiology · 2025Review
- How genomics can help unravel the evolution of endophytic fungi.World journal of microbiology & biotechnology · 2025Review
- The first chromosome-scale genome assembly of a microcyclic rust, Puccinia silphii.BMC genomics · 2025Article
- Genomics Research on the Road of Studying Biology and Virulence of Cereal Rust Fungi.Molecular plant pathology · 2025Review
- Exploring Environmental Microfungal Diversity Through Serial Single Cell Screening.Molecular ecology resources · 2025Article
- Reviving Élie Metschnikoff's Monospora: the obligately parasitic yeast Australozyma monospora sp. nov.FEMS yeast research · 2025Article
- Plant reproductive suppression triggers fatty acid-mediated enrichment of Mortierella for enhanced stress resilience.The ISME journal · 2025Article
- The first single-cell sequencing ofFrontiers in microbiology · 2025Article
- Poplar: a phylogenomics pipeline.Bioinformatics advances · 2025Article
- Thirty novel fungal lineages: formal description based on environmental samples and DNA.MycoKeys · 2025Article
- Tools for microbial single-cell genomics for obtaining uncultured microbial genomes.Biophysical reviews · 2024Review
- Incorporating omics-based tools into endophytic fungal research.Biotechnology notes (Amsterdam, Netherlands) · 2024Review
- Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental DNA surveys reveal that most fungal diversity represents uncultured species. We sequenced the genomes of eight uncultured species across the fungal tree of life using a new single-cell genomics pipeline. We show that, despite a large variation in genome and gene space recovery from each single amplified genome (SAG), ≥90% can be recovered by combining multiple SAGs. SAGs provide robust placement for early-diverging lineages and infer a diploid ancestor of fungi. Early-diverging fungi share metabolic deficiencies and show unique gene expansions correlated with parasitism and unculturability. Single-cell genomics holds great promise in exploring fungal diversity, life cycles and metabolic potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.