ArticleNature communications2018
A sulfotransferase dosage-dependently regulates mouthpart polyphenism in the nematode Pristionchus pacificus.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- The histone code at a crossroads: history, context, and new approaches.Trends in genetics : TIG · 2026Review
- Practical indistinguishability in a gene regulatory network inference problem, a case study.ArXiv · 2025Article
- Genomic parallelism defines repeated evolution of an inducible offense.Science advances · 2025Article
- Functional divergence of conserved developmental plasticity genes between two distantly related nematodes.Scientific reports · 2025Article
- Developmental transcriptomics inGenome research · 2025Article
- EBAX-1/ZSWIM8 destabilizes miRNAs, resulting in transgenerational inheritance of a predatory trait.Science advances · 2025Article
- High Nutritional Conditions Influence Feeding Plasticity in Pristionchus pacificus and Render Worms Non-Predatory.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Review
- Genetic regulators of a resource polyphenism interact to couple predatory morphology and behaviour.Proceedings. Biological sciences · 2024Article
- Conserved switch genes that arose via whole-genome duplication regulate a cannibalistic nematode morph.Science advances · 2024Article
- Evolution and molecular mechanisms of wing plasticity in aphids.Current opinion in insect science · 2024Review
- Spatial and temporal heterogeneity alter the cost of plasticity in Pristionchus pacificus.PLoS computational biology · 2024Article
- A histone demethylase links the loss of plasticity to nongenetic inheritance and morphological change.Nature communications · 2023Article
- Kin-recognition and predation shape collective behaviors in the cannibalistic nematode Pristionchus pacificus.PLoS genetics · 2023Article
- Co-option of an Astacin Metalloprotease Is Associated with an Evolutionarily Novel Feeding Morphology in a Predatory Nematode.Molecular biology and evolution · 2023Article
- A Mediator subunit imparts robustness to a polyphenism decision.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form.Nature communications · 2023Article
- Influence of environmental temperature on mouth-form plasticity in Pristionchus pacificus acts through daf-11-dependent cGMP signaling.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
- Experimental and theoretical support for costs of plasticity and phenotype in a nematode cannibalistic trait.Evolution letters · 2023Article
- Evolution and Diversity of TGF-β Pathways are Linked with Novel Developmental and Behavioral Traits.Molecular biology and evolution · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Polyphenism, the extreme form of developmental plasticity, is the ability of a genotype to produce discrete morphologies matched to alternative environments. Because polyphenism is likely to be under switch-like molecular control, a comparative genetic approach could reveal the molecular targets of plasticity evolution. Here we report that the lineage-specific sulfotransferase SEUD-1, which responds to environmental cues, dosage-dependently regulates polyphenism of mouthparts in the nematode Pristionchus pacificus. SEUD-1 is expressed in cells producing dimorphic morphologies, thereby integrating an intercellular signalling mechanism at its ultimate target. Additionally, multiple alterations of seud-1 support it as a potential target for plasticity evolution. First, a recent duplication of seud-1 in a sister species reveals a direct correlation between genomic dosage and polyphenism threshold. Second, inbreeding to produce divergent polyphenism thresholds resulted in changes in transcriptional dosage of seud-1. Our study thus offers a genetic explanation for how plastic responses evolve.
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