ArticlePharmaceutics2018
Fabrication and Characterization of Strontium-Substituted Hydroxyapatite-CaO-CaCO₃ Nanofibers with a Mesoporous Structure as Drug Delivery Carriers.
Article in Pharmaceutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Strontium-substituted hydroxyapatite nanoparticles as dual-function regulators of osteoblast mineralization and RANKL-induced osteoclastogenesis.Journal of materials science. Materials in medicine · 2026Article
- Strontium-doped hydroxyapatite microspheres loaded with iloprost promote dentin-pulp complex regeneration.Frontiers in bioengineering and biotechnology · 2025Article
- Harnessing strontium in regenerative dentistry: progress and perspectives.Frontiers in bioengineering and biotechnology · 2025Review
- Applications of Bioactive Strontium Compounds in Dentistry.Journal of functional biomaterials · 2024Review
- Modern Microbiological Methods to Detect Biofilm Formation in Orthopedy and Suggestions for Antibiotic Therapy, with Particular Emphasis on Prosthetic Joint Infection (PJI).Microorganisms · 2024Review
- A Comparative Study on Physicochemical Properties andACS applied bio materials · 2023Article
- Metal Ion-Doped Hydroxyapatite-Based Materials for Bone Defect Restoration.Bioengineering (Basel, Switzerland) · 2023Review
- Article
- Sol-Gel Technologies to Obtain Advanced Bioceramics for Dental Therapeutics.Molecules (Basel, Switzerland) · 2023Review
- Synthesis and Antimicrobial Analysis of High Surface Area Strontium-Substituted Calcium Phosphate Nanostructures for Bone Regeneration.International journal of molecular sciences · 2023Article
- Preparation of hydroxyapatite nanofibers by using ionic liquids as template and application in enhancing hydrogel performance.Frontiers in bioengineering and biotechnology · 2023Article
- Influence of the Components and Orientation of Hydroxyapatite Fibrous Substrates on Osteoblast Behavior.Journal of functional biomaterials · 2022Article
- Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review.Materials (Basel, Switzerland) · 2022Review
- Polycaprolactone/Gelatin/Hydroxyapatite Electrospun Nanomembrane Materials Incorporated with Different Proportions of Attapulgite Synergistically Promote Bone Formation.International journal of nanomedicine · 2022Article
- The Effect of Strontium-Substituted Hydroxyapatite Nanofibrous Matrix on Osteoblast Proliferation and Differentiation.Membranes · 2021Article
- Ce/Sm/Sr-Incorporating Ceramic Scaffolds Obtained via Sol-Gel Route.Materials (Basel, Switzerland) · 2021Article
- Preparation of a New Biocomposite Designed for Cartilage Grafting with Antibiofilm Activity.ACS omega · 2020Article
- Hydroxyapatite based biocomposite scaffold: A highly biocompatible material for bone regeneration.Saudi journal of biological sciences · 2020Article
- A 3D Bioprinted Pseudo-Bone Drug Delivery Scaffold for Bone Tissue Engineering.Pharmaceutics · 2020Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Hydroxyapatite (HAp) is the main inorganic component and an essential part of hard bone and teeth. Due to its excellent biocompatibility, bioactivity, and osteoconductivity, synthetic HAp has been widely used as a bone substitute, cell carrier, and therapeutic gene or drug carrier. Recently, numerous studies have demonstrated that strontium-substituted hydroxyapatite (SrHAp) not only enhances osteogenesis but also inhibits adipogenesis in mesenchymal stem cells. Mesoporous SrHAp has been successfully synthesized via a traditional template-based process and has been found to possess better drug loading and release efficiencies than SrHAp. In this study, strontium-substituted hydroxyapatite-CaO-CaCO₃ nanofibers with a mesoporous structure (mSrHANFs) were fabricated using a sol⁻gel method followed by electrospinning. X-ray diffraction analysis revealed that the contents of CaO and CaCO₃ in the mSrHANFs decreased as the doping amount of Sr increased. Scanning electron microscopy (SEM) images showed that the average diameter of the mSrHANFs was approximately 200~300 nm. The N₂ adsorption⁻desorption isotherms demonstrated that the mSrHANFs possessed a mesoporous structure and that the average pore size was approximately 20~25 nm. Moreover, the mSrHANFs had excellent drug- loading efficiency and could retard the burst release of tetracycline (TC) to maintain antibacterial activity for over 3 weeks. Hence, mSrHANFs have the potential to be used as drug carriers in bone tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.