Trial reportBMJ (Clinical research ed.)2018
Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute cholecystitis in high risk patients (CHOCOLATE): multicentre randomised clinical trial.
Trial report in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 136 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cholecystectomy Could be Performed in Adults Older Than 80 Years Old With Mild to Moderate Acute Cholecystitis
SnapChole: An International, Time-Bound Prospective Platform Study of Management Strategies and Outcomes in Acute Calculous Cholecystitis
Who cites it
136 citing papers in PubMed, 10 syntheses or guidelines pooled it, 296 citations in OpenAlex.
- Endoscopic ultrasound-guided versus percutaneous transhepatic gallbladder drainage in surgically high-risk patients with acute cholecystitis: a systematic review and meta-analysis.Surgical endoscopy · 2026Pooled it
- Comparing percutaneous treatment and cholecystectomy outcomes in acute cholecystitis patients: a systematic review and meta-analysis.World journal of emergency surgery : WJES · 2025Pooled it
- Percutaneous cholecystostomy in elderly patients with acute cholecystitis: a systematic review and meta-analysis.Updates in surgery · 2024Pooled it
- Prophylactic cholecystectomy offers best outcomes following ERCP clearance of common bile duct stones: a meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Pooled it
- Percutaneous cholecystostomy versus emergency cholecystectomy for the treatment of acute calculous cholecystitis in high-risk surgical patients: a meta-analysis and systematic review.Updates in surgery · 2022Pooled it
- Comparison of emergency cholecystectomy and delayed cholecystectomy after percutaneous transhepatic gallbladder drainage in patients with acute cholecystitis: a systematic review and meta-analysis.Updates in surgery · 2021Pooled it
- The management of surgical patients in the emergency setting during COVID-19 pandemic: the WSES position paper.World journal of emergency surgery : WJES · 2021Guideline
- 2020 World Society of Emergency Surgery updated guidelines for the diagnosis and treatment of acute calculus cholecystitis.World journal of emergency surgery : WJES · 2020Guideline
- Perioperative outcomes after laparoscopic cholecystectomy in elderly patients: a systematic review and meta-analysis.Surgical endoscopy · 2020Pooled it
- Safe cholecystectomy multi-society practice guideline and state-of-the-art consensus conference on prevention of bile duct injury during cholecystectomy.Surgical endoscopy · 2020Guideline
- Fast Track Pathway to Accelerated Cholecystectomy Versus Standard of Care for Acute Cholecystitis (FAST) pilot trial.Canadian journal of surgery. Journal canadien de chirurgieTrial
- Return to intended oncologic therapy after treatment for cholecystitis in cancer patients.Surgery · 2026Article
- Technical Evolution, Clinical Application, and Outcomes of Endoscopic Transpapillary Gallbladder Drainage in Acute Cholecystitis: A Review.Journal of clinical medicine · 2026Review
- Emergency Cholecystectomy in Patients Classified as High Risk According to the Tokyo Guidelines 2018: A Real-World Analysis.Annals of gastroenterological surgery · 2026Article
- Interventional Radiology in Acute Cholecystitis: A Review of Contemporary Percutaneous Strategies and Emerging Techniques.Journal of clinical medicine · 2026Review
- Percutaneous versus surgical treatment of acute cholecystitis.World journal of emergency surgery : WJES · 2026Article
- Endoscopic-Ultrasound-Guided Gallbladder Drainage in Patients with Percutaneous Cholecystostomy Drain.Journal of clinical medicine · 2026Article
- Age-Adjusted Charlson Comorbidity Index as a Predictor of Clinical Severity in Acute Cholecystitis: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Adoption of robotic interval cholecystectomy: a retrospective comparison with the laparoscopic approach at a single center.Surgical endoscopy · 2026Article
- Observational
76 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess whether laparoscopic cholecystectomy is superior to percutaneous catheter drainage in high risk patients with acute calculous cholecystitis.
designMulticentre, randomised controlled, superiority trial.
setting11 hospitals in the Netherlands, February 2011 to January 2016.
participants142 high risk patients with acute calculous cholecystitis were randomly allocated to laparoscopic cholecystectomy (n=66) or to percutaneous catheter drainage (n=68). High risk was defined as an acute physiological assessment and chronic health evaluation II (APACHE II) score of 7 or more.
main outcome measuresThe primary endpoints were death within one year and the occurrence of major complications, defined as infectious and cardiopulmonary complications within one month, need for reintervention (surgical, radiological, or endoscopic that had to be related to acute cholecystitis) within one year, or recurrent biliary disease within one year.
resultsThe trial was concluded early after a planned interim analysis. The rate of death did not differ between the laparoscopic cholecystectomy and percutaneous catheter drainage group (3%
conclusionLaparoscopic cholecystectomy compared with percutaneous catheter drainage reduced the rate of major complications in high risk patients with acute cholecystitis.
trial registrationDutch Trial Register NTR2666.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.