ArticleProceedings of the National Academy of Sciences of the United States of America2018
Genetic variation in the
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Multi-ancestry investigation of the genomics of erectile dysfunction.Nature communications · 2025Pooled it
- Genetic Prediction of Erectile Dysfunction Caused by Statins Among Malaysian Cardiac Patients.International journal of molecular sciences · 2025Article
- Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele.Nature communications · 2025Article
- Association Between Fine Particle Waves and Sexual Function: A Nationwide Cross-Sectional Survey in China.Toxics · 2025Article
- Structural framework to address variant-gene relationship in primary open-angle glaucoma.Vision research · 2025Review
- Genetic factors associated with erectile dysfunction- mendelian randomisation analysis.American journal of clinical and experimental urology · 2025Article
- Lipid metabolism and neuromuscular junction as common pathways underlying the genetic basis of erectile dysfunction and obstructive sleep apnea.International journal of impotence research · 2024Article
- A Mendelian randomisation approach to explore genetic factors associated with erectile dysfunction based on pooled genomic data.American journal of clinical and experimental urology · 2024Article
- Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie's Disease.International journal of molecular sciences · 2023Review
- Genetics and erectile dysfunction: leveraging early foundations for new discoveries.International journal of impotence research · 2022Review
- Positively selected genes in the hoary bat (PeerJ · 2022Article
- Transcription factor gene Pea3 regulates erectile function during copulation in mice.PloS one · 2022Article
- Phosphodiesterase Type 5 Inhibitors and Risk of Skin Cancers in Men: A Meta-Analysis and Trial Sequential Analysis Involving 7,479,852 Subjects.The world journal of men's health · 2021Article
- Article
- Review
- Some concerns regarding the association of rs17185536 in SIM1 with erectile dysfunction.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Emerging Treatments for Erectile Dysfunction: a Review of Novel, Non-surgical Options.Current urology reports · 2019Review
- Genetic variant rs17185536 regulatesProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Reply to Liu et al.: Tissue specificity ofProceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
Erectile dysfunction affects millions of men worldwide. Twin studies support the role of genetic risk factors underlying erectile dysfunction, but no specific genetic variants have been identified. We conducted a large-scale genome-wide association study of erectile dysfunction in 36,649 men in the multiethnic Kaiser Permanente Northern California Genetic Epidemiology Research in Adult Health and Aging cohort. We also undertook replication analyses in 222,358 men from the UK Biobank. In the discovery cohort, we identified a single locus (rs17185536-T) on chromosome 6 near the single-minded family basic helix-loop-helix transcription factor 1 (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.