Evidence map›Paper›PMID 30297414›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

MRI-based assessment of function and dysfunction in myelinated axons.

William M Spees, Tsen-Hsuan Lin, Peng Sun, Chunyu Song, Ajit George, Sam E Gary, Hsin-Chieh Yang, Sheng-Kwei Song

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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  9. Length-dependent MRI of hereditary neuropathy with liability to pressure palsies.Annals of clinical and translational neurology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

William M SpeesBiomedical MR Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110; spees@wustl.edu.
Tsen-Hsuan LinBiomedical MR Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
Peng SunBiomedical MR Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
Chunyu SongDepartment of Biomedical Engineering, Washington University, St. Louis, MO 63110.
Ajit GeorgeBiomedical MR Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
Sam E GaryBiomedical MR Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-6526-4953
Hsin-Chieh YangBiomedical MR Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
Sheng-Kwei SongBiomedical MR Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
Mallinckrodt (United States) · USWashington University in St. Louis · US

Funding

Validating diffusion MRI biomarkers of inflammation and axon pathologies in EAEP01NS059560 · NINDS · WASHINGTON UNIVERSITY · PI SONG, SHENG-KWEI · 2008 to 2018
$11.3M
PREDICTIVE VALUE OF DIFFUSION MRI IN CERVICAL SPONDYLOTIC MYELOPATHYR01NS047592 · NINDS · WASHINGTON UNIVERSITY · PI RAY, WILSON Z, SONG, SHENG-KWEI · 2005 to 2021
$5.8M
IMAGING OPTIC NERVE FUNCTION AND PATHOLOGYU01EY025500 · NEI · WASHINGTON UNIVERSITY · PI SONG, SHENG-KWEI · 2015 to 2019
$3.1M
NEI NIH HHS U01 EY025500NINDS NIH HHS P01 NS059560NINDS NIH HHS R01 NS047592
6 · The paper itself

Abstract

Repetitive electrical activity produces microstructural alteration in myelinated axons, which may afford the opportunity to noninvasively monitor function of myelinated fibers in peripheral nervous system (PNS)/CNS pathways. Microstructural changes were assessed via two different magnetic-resonance-based approaches: diffusion fMRI and dynamic T

Indexed as

AnimalsAnuraAxonsBrain MappingDiffusionDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingImage Processing, Computer-AssistedMyelin SheathNerve Fibers, MyelinatedSciatic Nerveaction potentialdiffusion MRIfMRImyelinwhite matter

Identifiers

PMID30297414
PMCPMC6205472
OpenAlexW2897716152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.