ArticleProceedings of the National Academy of Sciences of the United States of America2018
Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Canonical and Non-Canonical Antipsychotics' Dopamine-Related Mechanisms of Present and Next Generation Molecules: A Systematic Review on Translational Highlights for Treatment Response and Treatment-Resistant Schizophrenia.International journal of molecular sciences · 2023Pooled it
- Prior Expectations of Volatility Following Psychotherapy for Delusions: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Dopamine manipulations modulate paranoid social inferences in healthy people.Translational psychiatry · 2020Trial
- Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.Human brain mapping · 2026Article
- SN/VTA neuromelanin signal is associated with subclinical paranoia irrespective of familial risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- The joint estimation of uncertainty and its relationship with psychotic-like traits and psychometric schizotypy.Npj mental health research · 2025Article
- Higher-order and distributed synergistic functional interactions encode information gain in goal-directed learning.Nature communications · 2025Article
- Frequency-specific changes in prefrontal activity associated with maladaptive belief updating in volatile environments in euthymic bipolar disorder.Translational psychiatry · 2025Article
- Neural correlates of reduced sensitivity to information about uncertainty during valuation in older adults: An fNIRS study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neural correlates of uncertainty processing in psychosis spectrum disorder.Brain communications · 2025Article
- Understanding Cognitive Behavioral Therapy for Psychosis Through the Predictive Coding Framework.Biological psychiatry global open science · 2024Review
- D2/D3 dopamine supports the precision of mental state inferences and self-relevance of joint social outcomes.Nature. Mental health · 2024Article
- Long-term, multi-event surprise correlates with enhanced autobiographical memory.Nature human behaviour · 2023Article
- Blocking D2/D3 dopamine receptors in male participants increases volatility of beliefs when learning to trust others.Nature communications · 2023Article
- Pathways to the persistence of drug use despite its adverse consequences.Molecular psychiatry · 2023Review
- Accelerated atrophy in dopaminergic targets and medial temporo-parietal regions precedes the onset of delusions in patients with Alzheimer's disease.European archives of psychiatry and clinical neuroscience · 2023Article
- Belief Updating in Subclinical and Clinical Delusions.Schizophrenia bulletin open · 2023Article
- Striatal correlates of Bayesian beliefs in self-efficacy in adolescents and their relation to mood and autonomy: a pilot study.Cerebral cortex communications · 2023Article
- Computational mechanisms of belief updating in relation to psychotic-like experiences.Frontiers in psychiatry · 2023Article
- A New Explanation for the Frog-in-the-Pan Phenomenon Based on the Cognitive-Evolutionary Model of Surprise.Behavioral sciences (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Distinguishing between meaningful and meaningless sensory information is fundamental to forming accurate representations of the world. Dopamine is thought to play a central role in processing the meaningful information content of observations, which motivates an agent to update their beliefs about the environment. However, direct evidence for dopamine's role in human belief updating is lacking. We addressed this question in healthy volunteers who performed a model-based fMRI task designed to separate the neural processing of meaningful and meaningless sensory information. We modeled participant behavior using a normative Bayesian observer model and used the magnitude of the model-derived belief update following an observation to quantify its meaningful information content. We also acquired PET imaging measures of dopamine function in the same subjects. We show that the magnitude of belief updates about task structure (meaningful information), but not pure sensory surprise (meaningless information), are encoded in midbrain and ventral striatum activity. Using PET we show that the neural encoding of meaningful information is negatively related to dopamine-2/3 receptor availability in the midbrain and dexamphetamine-induced dopamine release capacity in the striatum. Trial-by-trial analysis of task performance indicated that subclinical paranoid ideation is negatively related to behavioral sensitivity to observations carrying meaningful information about the task structure. The findings provide direct evidence implicating dopamine in model-based belief updating in humans and have implications for understating the pathophysiology of psychotic disorders where dopamine function is disrupted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.