Evidence map›Paper›PMID 30297402›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Functional and evolutionary characterization of a secondary metabolite gene cluster in budding yeasts.

David J Krause, Jacek Kominek, Dana A Opulente, Xing-Xing Shen, Xiaofan Zhou, Quinn K Langdon, Jeremy DeVirgilio, Amanda Beth Hulfachor, Cletus P Kurtzman, Antonis Rokas and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 112 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Chromosome-level genome assembly of a kombucha isolate ofMicrobiology resource announcements · 2026
    Article
  5. Confrontations betweenApplied and environmental microbiology · 2026
    Article
  6. Pulcherrimin and Beyond: The Multifaceted Role ofJournal of fungi (Basel, Switzerland) · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Core gene set of the speciesbioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

David J KrauseLaboratory of Genetics, Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, WI 53706.
Jacek KominekLaboratory of Genetics, Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, WI 53706.
Dana A OpulenteLaboratory of Genetics, Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, WI 53706.
Xing-Xing ShenDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235.
Xiaofan ZhouDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235.
Quinn K LangdonLaboratory of Genetics, Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, WI 53706.
Jeremy DeVirgilioMycotoxin Prevention and Applied Microbiology Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, US Department of Agriculture, Peoria, IL 61604.
Amanda Beth HulfachorLaboratory of Genetics, Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, WI 53706.
Cletus P KurtzmanMycotoxin Prevention and Applied Microbiology Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, US Department of Agriculture, Peoria, IL 61604.
Antonis RokasDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235.ORCID 0000-0002-7248-6551
Chris Todd HittingerLaboratory of Genetics, Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, WI 53706; cthittinger@wisc.edu.ORCID 0000-0001-5088-7461
University of Wisconsin–Madison · USVanderbilt University · USAgricultural Research Service · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
NIGMS NIH HHS T32 GM007133
6 · The paper itself

Abstract

Secondary metabolites are key in how organisms from all domains of life interact with their environment and each other. The iron-binding molecule pulcherrimin was described a century ago, but the genes responsible for its production in budding yeasts have remained uncharacterized. Here, we used phylogenomic footprinting on 90 genomes across the budding yeast subphylum Saccharomycotina to identify the gene cluster associated with pulcherrimin production. Using targeted gene replacements in

Indexed as

IronKluyveromycesMembrane Transport ProteinsMultigene FamilyPhylogenyProtein BiosynthesisSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSaccharomycetalesSecondary MetabolismSiderophoresTranscription FactorsIronMembrane Transport ProteinsSaccharomyces cerevisiae ProteinsSiderophoresTranscription Factorsbudding yeastscyclodipeptide synthasegene clustersecondary metabolismsiderophore

Identifiers

PMID30297402
PMCPMC6205458
OpenAlexW2897543027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.